Aaron Frederick Severson (Aaron), Ph. D
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 Title: Assistant Professor
Adjunct Staff, Department of Molecular Genetics, Cleveland Clinic
 Dept: Biological, Geological and Environmental Sciences
 Office: SR 275,276
 Phone: 216-687-4864
 Email: A.SEVERSON@csuohio.edu
 Web: http://www.csuohio.edu/grhd/faculty/aaron-severson
 Address: 2121 Euclid Ave. SR 275,276, Cleveland, OH 44115

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Research Keywords:
Caenorhabditis elegans, chromosomal biology, chromosome segregation, cohesin, chromosome segregation, DNA repair, genomic instability, meiosis, reproductive health, sister chromatid cohesion
 
Education:
Ph.D., Biology, University of Oregon, 2001
B.S., Biology, University of Wisconsin, 1994
 
Brief Bio:
2013-Present  Member, Center for Gene Regulation in Health and Disease (GRHD)
2012-Present  Assistant Professor, Cleveland State University, BGES Department
2006-2012  Associate Specialist, University of California, MCB Department
2002-2006  Postdoctoral Researcher, University of California, MCB Department
2001-2002  Postdoctoral Researcher, University of Oregon, Department of Biology
1995-2001  Graduate Research Assistant, University of Oregon, Department of Biology
1994-1995  Research Specialist, University of Wisconsin, Department of Biology
1993-1993  Undergraduate Researcher, University of Wisconsin, Department of Biology
 
Honors and Awards:
Helen Hay Whitney Foundation Postdoctoral Fellowship, 2003-2006
 
Research Interests:
In all organisms, accurate transmission of the genome during cell division is essential to prevent genetic instability. This is especially true during meiosis, the process that reduces genome copy number, or ploidy, from two in diploid germline stem cells to one in each haploid gamete. Defects in meiosis affect all cells of an embryo and profoundly impact health: it is estimated that over 30% of human zygotes have abnormal chromosomal content at conception, and such aneuploidies are the leading known cause of miscarriages and birth defects. The best known viable aneuploidy, trisomy 21, causes Down syndrome. I use Caenorhabditis elegans to study how gametes inherit exactly one copy of every chromosome. Because the process of meiosis is widely conserved among eukaryotes, the meiotic mechanisms we identify in the lowly worm are relevant to understanding gametogenesis in humans.
 
Teaching Areas:
Genetics, Developmental Biology, Molecular Biology
 
Professional Affiliations:
American Society for Cell Biology
Genetics Society of America
 
Professional Experience:
2013-Present Member, Cleveland State University Graduate Faculty
2013-Present Member, Center for Gene Regulation in Health and Disease (GRHD)
2013-2015 Adjunct Staff, Department of Molecular Genetics, Cleveland Clinic
2012-Present Assistant Professor, Cleveland State University, BGES Department
2006-2012 Associate Specialist, University of California, MCB Department
2002-2006 Postdoctoral Researcher, University of California, MCB Department
 
University Service:
2016-Present  BGES Undergraduate Program Director
2015-Present  COSHP Budget and Planning Committee
2015-Present  BGES Undergraduate Committee on Curriculum and Academic Standards
2013-2015  BGES Departmental Secretary
 
Professional Service:
Scientific journal ad hoc reviewer: EMBO J, G3
 
Community Service:
2015  Session Chair, EMBO Workshop, SMC proteins: Chromosomal organizers from bacteria to human
2015  Co-organizer, Midwest Meiosis Meeting
2015-Present  Western Reserve University, Institutional Review Entity
2014  Special Judge, NEOSEF Science Fair
2012-Present  Case Western Reserve University, Institutional Biosafety Committee
 
Research Grants:
Active:

NIH 1R15GM117548-01 (2016-2019): Severson, AF PI
"Specification of meiotic cohesin function by divergent alpha-kleisin subunits"