| Title: | Associate Professor |
| Dept: | Chemistry |
| Office: | SI 424 |
| Phone: | 216-687-2416 |
| Email: | A.ZHOU@csuohio.edu |
| Address: | 2121 Euclid Ave. SI 424, Cleveland, OH 44115 |
Education: | ||
|
B.S., Organic chemistry, Zhongshan University, 1982
M.S., Biochemistry, Institute of Microbiology,CAS, 1985 Ph.D., Clinical Chemistry, Cleveland State University, 1998 | ||
| Brief Bio: | ||
| 8/2005- present:Associate Professor, Clinical Chemistry Program,
Department of Chemistry, Cleveland State University, Cleveland, Ohio 9/2000-8/2005: Assistant Professor, Clinical Chemistry Program, Department of Chemistry,Cleveland State University, Cleveland, Ohio 5/1999-8/2000: Project Scientist, Department of Cancer Biology, Cleveland Clinic Foundation,Cleveland,Ohio 8/1995-5/1999: Research Associate, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 8/1991-8/1995: Research Fellow, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 10/1987-8/1991: Visiting Scientist, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 10/1985-10/1987:Research Fellow, Department of Enzymology, Institute of Microbiology, The Chinese Academy of Sciences, Beijing, China | ||
| Honors and Awards: | ||
| 6/1991 : Sustained Superior Performance Award
Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda, Maryland 1988-1989: Outstanding Performance Award Uniformed Services University of the Health Sciences Bethesda, Maryland 1987-1988: Outstanding Performance Award Uniformed Services University of the Health Sciences Bethesda, Maryland | ||
| Research Interests: | ||
| RNase L is one of the key enzymes involved in the molecular mechanisms of interferon (IFN) function. Upon binding with its activator, 5'-phosphorylated and 2'-5' linked oligoadenylates (2-5A), RNase L plays an important role in the antiviral and anti-proliferative functions of IFN, and exerts proapoptotic activity independent of IFN. These biological activities are thought to occur through the RNase L-dependent regulation of RNA stability and expression; however, the molecular targets of RNase L remain largely unknown. Recently we have found that RNase L regulates the expression of several proinflammatory genes. Our research has focused on investigating the molecular mechanism by which RNase L regulates the expression of these proinflammatory genes and the role of RNase L in inflammatory diseases. | ||
| Teaching Areas: | ||
| Biotechnology
Clinical Chemistry General Chemistry | ||
| Professional Affiliations: | ||
| American Association for the Advancement of Science
American Association for Clinical Chemistry International Society for Interferon and Cytokine Research American Cancer Society | ||