Aimin Zhou
A_ZHOU.jpg
 Title: Professor
 Dept: Chemistry
 Office: SI 424
 Phone: 216-687-2416
 Email: A.ZHOU@csuohio.edu
 Address: 2121 Euclid Ave. SI 424, Cleveland, OH 44115

Courses Taught

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Research Keywords:
Interferon, RNase L, inflammatory diseases, gene expression
 
Education:
B.S., Organic chemistry, Zhongshan University, 1982
M.S., Biochemistry, Institute of Microbiology,CAS, 1985
Ph.D., Clinical Chemistry, Cleveland State University, 1998
 
Brief Bio:
2012-present:   Professor, Clinical Chemistry Program,
                Department of Chemistry, Cleveland State University, Cleveland, Ohio
2005-2012:      Associate Professor, Clinical Chemistry Program,
                Department of Chemistry, Cleveland State University, Cleveland, Ohio
2000-2005: Assistant Professor, Clinical Chemistry Program,  
                Department of Chemistry,Cleveland State University, Cleveland, Ohio
1999-2000: Project Scientist, Department of Cancer Biology,
                Cleveland Clinic Foundation,Cleveland,Ohio                                
1995-1999: Research Associate, Department of Cancer Biology,
Cleveland Clinic Foundation, Cleveland, Ohio
1991-1995: Research Fellow, Department of Cancer Biology,
Cleveland Clinic Foundation, Cleveland, Ohio
1987-1991: Visiting Scientist, Department of Pathology,
Uniformed Services University of the Health Sciences,
Bethesda, Maryland
1985-1987:      Research Fellow, Department of Enzymology,
Institute of Microbiology, The Chinese Academy of
Sciences, Beijing, China
 
Honors and Awards:
2012               Merit Recognition Award, Cleveland State University

2010/2011          Merit Recognition Award, Cleveland State University

2010               Outstanding Achievement Award
                   Chinese American Faculty and Staff Association
                   Cleveland State University

2008/2009          Merit Recognition Award, Cleveland State University

2007               Merit Recognition Award, Cleveland State University

2006               Merit Recognition Award, Cleveland State University

6/1991 : Sustained Superior Performance Award
Henry M. Jackson Foundation
for the Advancement of Military Medicine
Bethesda, Maryland
1988-1989: Outstanding Performance Award
Uniformed Services University of the Health Sciences
Bethesda, Maryland
1987-1988: Outstanding Performance Award
Uniformed Services University of the Health Sciences
Bethesda, Maryland
 
Research Interests:
RNase L is one of the key enzymes involved in the molecular mechanisms of interferon (IFN) function. Upon binding with its activator, 5'-phosphorylated and 2'-5' linked oligoadenylates (2-5A), RNase L plays an important role in the antiviral and anti-proliferative functions of IFN, and exerts proapoptotic activity independent of IFN. These biological activities are thought to occur through the RNase L-dependent regulation of RNA stability and expression; however, the molecular targets of RNase L remain largely unknown. Recently we have found that RNase L regulates the expression of several proinflammatory genes. Our research has focused on investigating the molecular mechanism by which RNase L regulates the expression of these proinflammatory genes and the role of RNase L in inflammatory diseases.
 
Teaching Areas:
Biotechnology
Clinical Chemistry
General Chemistry
 
Professional Affiliations:
American Association for the Advancement of Science
American Association for Clinical Chemistry
International Society for Interferon and Cytokine Research
American Cancer Society