Chandrasekhar Rama Kothapalli (Chandra Kothapalli)
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 Title: Associate Professor
 Dept: Chemical & Biomedical Engineering
 Office: FH 460
 Phone: 216-687-2562,  216-687-2562
 Fax: 216-687-9220
 Email: C.KOTHAPALLI@csuohio.edu
 Web: http://www.csuohio.edu/engineering/cell-and-tissue-en
gineering-lab/cell-and-tissue-engineering-lab
 Blog: http://scholar.google.com/citations?user=nwqrk4YAAAAJ
 Address: 2121 Euclid Ave. FH 460, Cleveland, OH 44115

Courses Taught

Publications


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Research Keywords:
Stem Cells (mesenchymal, embryonic, human/rat/mice), Regenerative medicine, Tissue engineering, Microfluidics, Biomaterials, Nanotechnology, Biomedicine, Soft materials, Rheology, Toxicology
 
Education:
Ph.D., Bioengineering, Clemson University, 2008
M.S., Materials Science & Engineering, University of Connecticut, 2005
M.S., Chemical Engineering, Mississippi State University, 2002
B.S., Chemical Engineering, Andhra University, India, 2000
 
Brief Bio:
Dr. Kothapalli earned Bachelor's in Chemical Engineering from Andhra University, India, and Master's degrees in Chemical Engineering and Materials Sciences from Mississippi State University and University of Connecticut, respectively. He received his PhD in Bioengineering from Clemson University in May 2008, where he identified and optimized biomolecular cues comprising extracellular matrix components and growth factors, for regenerating elastin in aortic aneurysmal blood vessels. During his Postdoctoral Fellowship in the Biological Engineering Department at the Massachusetts Institute of Technology, he developed microfluidic assays to evaluate neurite responses
to growth factor gradients in vitro, and investigated axonal targeting of projection neurons (e.g.,corticospinal motor neurons) in three dimensional cultures. At MIT, Dr. Kothapalli also identified the role of microenvironment (matrix composition, stiffness, porosity, growth factors) on embryonic stem cell differentiation into various neural and glial lineages, for wide-ranging applications in cell transplantation therapies. His postdoctoral work at CUNY on glioblastoma cell migration and proliferation in 3D milieu is funded by the "Emergent Behaviors of Integrated Cellular Systems" grant by NSF at CUNY.

So far, Chandra's research has resulted in two patents, more than 30 peer-reviewed publications in reputed journals and conference proceedings, and 60 conference and seminar presentations. Among his numerous honors, he is a member of Sigma XI, was the Presidential Scholar at the Medical University of South Carolina, and received Faculty Merit award at CSU.

At CSU, Dr. Kothapalli built a research program at the interface of engineering and medicine, with strong clinical applications in regenerating diseased or injured tissues and organs. Using state of the art bioengineering approaches, he integrated his background and expertise in stem cells, tissue engineering, biomaterials and nanotechnology for developing long-lasting solutions for vascular and neural clinical conditions. Specifically, his lab formulates strategies which encourage stem cell differentiation into multiple lineages on demand, and enhance their survival, functionality and integration into the host tissue post-implantation. Dr. Kothapalli anticipates significant improvement in the quality of life for those suffering with fatal neurodegenerative or cardiovascular conditions. His other interests include developing highly-specialized microfluidic platforms to understand molecular mechanisms and signaling pathways involved in heterotypic cellular interactions under chemogradients. These microfluidic devices will allow for precise control of the cellular and non-cellular microenvironment at physiologically relevant length- and time- scales. Given the interdisciplinary nature of this research, Dr. Kothapalli collaborates with researchers at CSU and Cleveland Clinic. He also spends significant amount of time in teaching and mentoring undergraduate and graduate students in chemical and biomedical engineering principles.

Dr. Kothapalli  holds an Adjunct Staff appointment in the Department of Biomedical Engineering at the Lerner Research Institute in Cleveland Clinic. He is also an Adjunct Assistant Professor in the Division of General Medical Sciences at the Case Western Reserve University School of Medicine.
 
Honors and Awards:
Member, Sigma XI, 2009

Presidential Scholar, Medical University of South Carolina, 2008

Student travel award, International Conference on Hyaluronan, 2007

Outstanding graduate student, Materials Science and Engineering Student Chapter, University of Connecticut, 2004-2005

Arthur E. Focke Leadershape Award, American Society for Materials, 2005

Second prize for Best Research Presentation, American Society for Materials, Hartford Student night, 2005

President, UConn Materials Science and Engineering Student Chapter, 2004

James Ruppen Graduate Fellowship, University of Connecticut, 2004
 
Creative and Activities:
Current Students:

Kam-Nyeong Yu, Ph.D. (Postdoctoral Fellow)

Jyotsna Joshi (PhD candidate)
Gautam Mahajan (PhD candidate)
Brian Hama (MS, CHE)
Ali Alhradaan (MS, CHE)
Marissa Sarsfield (BS, CHE, Honors Thesis)
Aaron Smith (BS, CHE Honors Thesis)
Edward Jira (BS, CHE)

Lab alumni:

Kurt Farrell (Ph.D., 2016, Currently Postdoctoral Fellow at Mt.Sinai School of Medicine)
Anjana Subramaniam (MS non-thesis, Currently at CSU)
Sara El-Nimer (MS non-thesis, Currently at CSU)
Arsela Gishto (MS Thesis, Currently Researcher at Cleveland Clinic)
Amanda Powell (MS Thesis, Currently with Northern Technologies International Corp.)
Sameera Tasneem (MS Thesis, Currently with Kremers Urban Pharmaceuticals)
Phillip Simmers (MS Thesis, Currently doctoral student at U.Cincinnati)
Michael Sawonik (MS Thesis, Currently Engineer at CIVCO Medical Solutions)
Brian Hama (BS Honors Thesis, Currently pursuing MS at CSU)
Randolph Cook (BS, Currently Engineer with PPG Industries)
James Deyling (BS Honors Thesis, Currently doing MS at CSU)
Brittany Kastan (BS, Currently Chemical Engineer at Verantis Corp.).
 
Research Interests:
Tissue Engineering, Regenerative Medicine, Biologically-inspired Materials, Applied Microfluidics, Stem Cell Therapy, Bioimaging, Nanotechnology in Biomedicine, Cancer biology
 
Teaching Areas:
Biomaterials
Tissue Engineering
Biomechanics
Chemical Engineering Methods
Microfluidics
 
Professional Affiliations:
American Heart Association
Society for Biomaterials (SFB)
Biomedical Engineering Society (BMES)
Vascular Biology Working Group
Materials Research Society, 2002-2005
American Society for Materials/ The Materials Society, 2002-2005
 
University Service:
Member, University Undergraduate Student Success Committee, CSU, 2016-18.

Chair, University Admissions and Standards Committee, CSU, 2015-16.

Member, University Admissions and Standards Committee, CSU, 2012-2015.

Faculty Secretary, Fenn College of Engineering, CSU, 2012-2013.

Search Committee Member for numerous Faculty and Staff recruitments, CSU, 2011-tilldate.
 
Professional Service:
Editorial Board Member: Journal of Tissue Science and Engineering, Journal of Regenerative Medicine.

Reviewer for >40 journals including Tissue Engineering, Biomaterials, Acta Biomaterialia, Journal of Royal Society-Interface, PlOS One, Integrative Biology, Materials Science and Engineering C, Materials Letters, Journal of Biotechnology Advances, Artificial Organs, Interface Focus, Bentham Science Publishers, Biomaterials Science.

Member, Abstract Committee, South Carolina Bioengineering Summit, 2007

Editor, Materials Science and Engineering Department Newsletter, University of Connecticut, 2003-05

American Society for Materials-Hartford, Executive committee member, 2005-06
 
Research Grants:
National Science Foundation
National Institutes of Health
CSU Research Foundation