Mekki Bayachou
M_BAYACHOU.jpg
 Title: Professor
 Dept: Chemistry
 Office: SI 421
 Phone: 216-875-9716
 Email: M.BAYACHOU@csuohio.edu
 Address: 2121 Euclid Ave. SI 421, Cleveland, OH 44115

Courses Taught

Publications


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Research Keywords:
Functional Biomaterials, Antithrombotic surfaces, Electron-transfer; Nitric oxide synthases; Metalloproteins; Metalloenzymes; Cyt P450s; Bio-electrochemistry; DNA-sensors; DNA-protein interaction; Small Molecule metabolite sensors; Nanotechnology
 
Education:
Ph.D., Université de Paris (Pierre-et-Marie-Curie, Paris VI) and The Ecole Normale Supérieure, Paris-France, 1996
 
Brief Bio:
2012-Present       Professor, Cleveland State University, Cleveland, OH
2005-2011:          Associate Professor, Cleveland State University, Cleveland, OH
03/2009-present:     Visiting Faculty, Department of Pathobiology, Lerner Research Institute
                                Cleveland Clinic, Cleveland, OH.

2001-2005:           Assistant Professor, Cleveland State University, Cleveland, OH
During 2000:         Visiting Asst. Professor, University of Padova, Italy
1998-2000:           Research Fellow, University of California, Irvine, CA
1997-1998:           Postdoctoral Fellow, Merit Scholarship Award, University of California
                            Irvine, Irvine, California.
1996:                      PhD, The Ecole Normale Supérieure and The University of Paris,
                             Paris, France
 
Honors and Awards:
2013:      University Merit Recognition Award, Cleveland State University
2012:       Jearl Walker Outstanding Teaching Award, CSU
2012:      Merit Research Award, Cleveland State University
2011:      Inductee to the National Academy of Inventors (CSU Chapter)
2011:      Past-Chair, Americal Chemical Society-Cleveland Section.
2010:    Chair, American Chemical Society-Cleveland Section.
2010:    Faculty Research Development (FRD grant) Award
2009:    Chair-Elect, American Chemical Society- Cleveland Section
2007    Distinguished Faculty Research Award, Cleveland State University
2006-2009: Advisory Board Member in NSF's inorganic Workshop
2009-2010: NSF Grant Award, Division of Chemistry-Bioinorganic chemistry
2008:    Faculty Merit Recognition Award for Research, CSU
2008:    Undergraduate Students Summer Research Program Award, Provost¿s Office, CSU
2008:    Outstanding student employee supervisor, CSU
2009:    Undergraduate Students Summer Research Program Award, Provost¿s Office, CSU
2003-2007:  Department of Energy Grant Award
2007:    Undergraduate Students Summer Research Program Award, Provost¿s Office, CSU
2005-:    Study section on NIH review panel, Washington DC
2005:    Inaugural Outstanding Research Award, Cleveland State University
2004:    Nominee for the Society of Electroanalytical Chemistry Young Investigator Award
2004:    Faculty Research Merit Award, Cleveland State University
2003:    New Faculty Research Development Award, Cleveland State University
2003:    Chemistry Department Teaching Award, Cleveland State University
2003:      Established Full-time Research Enhancement Award, Cleveland State University

2005-present:    Associate Professor, Cleveland State University, Cleveland, OH
03/2009-present: Visiting Faculty, Department of Pathobiology, Lerner Research Institute
                 Cleveland Clinic, Cleveland, OH.
2001-2005:       Assistant Professor, Cleveland State University, Cleveland, OH
During 2000:     Visiting Asst. Professor, University of Padova, Italy
1998-2000:       Research Fellow, University of California, Irvine, CA
1997-1998:       Postdoctoral Fellow, Merit Scholarship Award, University of California
                 Irvine, Irvine, California.
1996:            PhD, The Ecole Normale Supérieure and The University of Paris.

1996-1998:       Postdoctoral fellow, University of California, Irvine,    
                 CA
1996:            Highest Honors and University Award for Top 10% Ph.D. Degree in France,  
                 University of Paris and The Ecole Normale Surperieure Paris, France
During 94:       Visiting Scientist, J. Heyrovsky Institute, Prague, Czech Rep.
 
Creative and Activities:
* Engaging undergraduate students in research as a new platform for engaged teaching is
an ongoing activity that I maintain in my labs. Honors students and other
undergraduate students worked in research projects in my labs and received prestigious
awards from our department and regionally for their research accomplishments. Most of
them are co-authors in our papers. Some of them are was currently in medical schools or
in other graduate schools.
* On the graduate front, I continue to supervise the Interdisciplinary Research Club for
CSU and CCF graduate students in Chemistry that I founded. This club is sponsored by an
Award that I received from the College of A&S (New Faculty Research Award). The Club
meets for presentations and research update by students and for students. Graduate
students learn how to take an active role in their education process. They also mentor
undergraduate students, who are encouraged to participate and get involved in the
research culture early in their career. The graduate student in this Club organized an annual graduate interdisciplinary research symposium. The most recent regional interdisciplinary symposium included 9 talks and over 70 papers emphasizing the chemistry/biology interface with participation of various schools in the region.
 
Research Interests:
* Development of functional materials for sensing under physiological conditions (tissue  
  and live single cells)
* Nanotechnology and nanostructured materials
* Electron transfer in enzymes and other biological systems. Study of Electron Transfer  
  Reactions in metalloproteins and metalloenzymes, particularly cyt P450s and Nitric
  Oxide Syntheses (NOSs); Mechanistic and Kinetic Investigation and Structure-Function of
  Metalloproteins/Enzymes.
* Nitric Oxide Synthase (NOS): Structure-Function investigation, redox modulation and
  electrocatalysis in thin films.
* DNA-modified electrodes and DNA-decorated carbon nanotubes to study NO-induced DNA
  damage. Development of DNA-based Biosensors on Microelectrodes and Microchips. Base
  mismatch, DNA/Antitumor and DNA/Antibiotic Interactions. Study of DNA/Regulatory
  Proteins Interactions.
* Hydrogenase-modified electrodes for both generation and catalytic consumption of
  molecular hydrogen.
* Activation of nitroalkane xenobiotics by heme proteins in bilayered films.
* Heme proteins and catalysis in ionic liquid environment
* Improved sensors for nitric oxide and applications (tissue and live single cells)
* Thin films containing nitric oxide synthase as antithrombotic coatings for blood-
  contacting medical devices.
 
Teaching Areas:
Analytical Chemistry and Bioanalytical Chemistry
Materials and biological function
Macromolecular Structure and Dynamics
General Chemistry
 
Professional Affiliations:
* American Chemical Society and ACS-Analytical Division; ACS Local Section (served as
  Chair of the local section and now as Past-Chair)

* Member of the Executive Committee of the Organic and Biological Electrochemistry
  Division, The Electrochemical

* Electrochemical Society (ECS); ECS Local Section (Secretary of the executive
  committee);

* The Society for Electroanalytical Chemistry (SEAC)
 
Professional Experience:
I have over twenty years of experience in bioanalytical chemistry and applications to molecule-protein interactions and recognition in solution and on modified surfaces to gain insights on structure and function. We also worked on the design of functional biomaterials such antithobotic coatings for blood-contacting devices and DNA-modified carbon nanotubes for DNA damage sensing. In general, projects in our lab are at the interface of nanotechnology, bioanalytical chemistry, and biological chemistry to study problems relevant to the biomedical field
 
University Service:
Departmental committees or assignments:
  * Sheibley Committee
  * Served on the Search Committees of number of positions
  * Chair, Appointments Committee
  * Chair, Analytical Chemistry Division

College committees or assignments:
  * Served to review Natural Science Gen. Ed courses
  * COS  Rep. on the University's new Wright Center for Sensor Systems Engineering (WCSSE)
  * Served as Chair of the Faculty Affairs Committee (2009-2010)
  * Served on the COS Budget Committee (2009-2013)
  * Serves on the COS Budget Committee (2013)

University committees or assignments:
  * Served on the CSU Gen. Ed. Committee
  * Served on Gen. Ed. Implementation Committee
  * Reviewed courses submitted to fulfill the new Gen. Ed. Requirements
  * Served on Admission & Standards Committee
  * Member of Faculty Senate (Representing Graduate College) (2010-2012)
  * Chair of the Graduate Dean Search Committee (2011)
 
Professional Service:
* I periodically serve as reviewer for grants submitted to NSF and NIH
* I served as reviewer for grants submitted to DOE.
* I served as review and Panel member for NIH study sections on sensors and sensing devices
* I constantly serve as a reviewer for a number of professional journals, including    
   Journal of the American Chemical Society, Biochemistry, Analytical Chemistry, Biosensors
   and Bioelectronics, Langmuir, etc.
* NSF-Inorganic Workshop, Member of the Advisory Board, 2006-2009.
 
Community Service:
I served on the Ingenuity Festival, Cleveland, summer 2007 (Prepared and presented the Nanotechnology Corner)

I constantly volunteer for the CSU Faculty Lecture Program in local high schools and events

I also offer lectures on scientific topics to associations and social groups

Invited Lecturer at the Cleveland MENSA

Invited Lecturer, Continuing Education (Health Professionals)
 
Research Grants:
Current:
1- NSF Grant (National Science Foundation, Bayachou M.: Principal Investigator)
2- FRD Grant (Cleveland State and The Ohio Board of Regents, Bayachou M.: Principal  
   Investigator)
3- Ohio Third-Frontier Grant (State of Ohio, Bayachou M.: Co-PI)

Completed:
1- DOE Grant (Department of Energy, Bayachou M.: Principal Investigator)
2- AHA Grant (American Heart Association Grant-in-Aid, Bayachou M.:Principal Investigator)
3- NIH Grant (The National Institutes of Health, Bayachou M.:Principal Investigator)
4- FRD Grant (Cleveland State and The Ohio Board of Regents, Bayachou M.: Principal  
   Investigator)
5- ACS 2 Pilot Grants (American Cancer Society, Bayachou M.: Principal Investigator).
6- CSU Start-up (Start-up Award, Bayachou M. Principal Investigator).