Moo-Yeal Lee, Ph.D.
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 Title: Assistant Professor
 Dept: Chemical & Biomedical Engineering
 Office: FH 439
 Phone: 216-687-9399
 Fax: 216-687-9220
 Email: M.LEE68@csuohio.edu
 Address: 2121 Euclid Ave. FH 439, Cleveland, OH 44115

Courses Taught

Publications


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Research Keywords:
- Microarray bioprinting/3D bioprinting, - Development of miniaturized biochemical and cell-based assays on a chip for drug discovery, - Gene transduction on a chip to emulate human liver for toxicology screening, - RNA interference on a chip to elucidate mechanisms of cellular responses for human toxicology, - Construction of miniaturized human tissues by printing primary human cell types for drug screening and personalized cancer therapy
 
Education:
B.S., Chemical Engineering, Gyeong Sang National University, 1993
M.S., Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), 1995
Ph.D., Chemical and Biomolecular Engineering, KAIST, 1999
JSPS Postdoctoral Fellow, Chemical Engineering, Tokyo Institute of Technology, 2001
Postdoctoral Research Scientist, Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 2004
 
Brief Bio:
Dr. Lee earned his Bachelor's Degree in Chemical Engineering from Gyeong Sang National University, South Korea, and a Master's Degree in Chemical and Biomolecular Engineering from KAIST (formerly known as Korea Advanced Institute of Science and Technology), where he also received his Ph.D. in Chemical and Biomolecular Engineering. Following graduation, he spent two years at Tokyo Institute of Technology, Japan, as a Postdoctoral Fellow supported by the Japan Society for the Promotion of Science, and three years at Rensselaer Polytechnic Institute, New York, as a Postdoctoral Research Scientist. Dr. Lee's work in microarray chip technology began as a lead senior scientist at Solidus Biosciences, Inc., a startup company that specialized in microarray chip technologies with applications in drug development. Dr. Lee has received A Successful Fellow of Korea-Japan Researchers' Friendship Award, and Postdoctoral Fellowships from the Japan Society for the Promotion of Science and the Korea Science and Engineering Foundation. His work has been highlighted by the Biological Research Information Center, a renowned research center in South Korea, and in other news outlets throughout the U.S.
Through Cleveland State University, Solidus Biosciences, Inc., and Rensselaer Polytechnic Institute, Dr. Lee has focused on developing highly automatable, high-throughput microarray screening platforms and associated instruments and devices that can be used for biochemical and cell-based assays to assess human metabolism and toxicology. Specific areas of current research include various microarray biochip platforms such as carbohydrate, enzyme, virus, and cell-based microarrays. Dr. Lee's contributions, among others, include the metabolizing enzyme toxicology assay chip (MetaChip), the data analysis toxicology assay chip (DataChip), the metabolic stability assay chip (MesaChip), and the metabolism chip (TeamChip), with research funding from the National Science Foundation and the National Institutes of Health, as well as from L'Oreal, Pfizer, and Samsung Electro-Mechanics, Co. Dr. Lee has published 52 papers in peer-reviewed journals, 1 book, and 2 book chapters, and have 18 patents and patent applications.
Dr. Lee's research goal at Cleveland State University is to develop innovative microarray biochip platforms and miniaturized biochemical and cell-based assays in droplets as small as 30 - 900 nanoliters for predictive, low-cost, high throughput evaluation of drug toxicity and efficacy. Dr. Lee envisions that "microarray 3D bioprinting" on the chip offers new opportunities for creating highly organized multicellular tissue constructs in vitro by dispensing multiple human cells in hydrogels layer-by-layer precisely with printing robots and mimicking the microenvironment of tissues in vivo, thereby potentially revolutionizing regenerative medicine, oncology, and drug discovery.
 
Honors and Awards:
1996 A Successful Fellow of Korea-Japan Researchers' Friendship Program, Korea-Japan Cooperation Foundation for Industry and Technology (KJF)
1997 Short-Term Student Exchange Promotion Program (Peace and Friendship Scholarship), Association of International Education, Japan (AIEJ)
1999 Postdoctoral Fellowship Program for Successful Foreign Researcher, Japan Society for the Promotion of Science (JSPS)
2001 Postdoctoral Fellowship Program, Korea Science and Engineering Foundation (KOSEF)
2005, 8, & 14 "People glorifying Korea", Biological Research Information Center (BRIC) in Korea
2016 Faculty Merit Recognition Award by Cleveland State University
2016 Semi-Finalist of Transform Tox Testing Challenge by EPA and NIH
2017 Faculty Merit Recognition Award by Cleveland State University
2017 I-Corps@Ohio MedTech Cohort by The Ohio Department of Higher Education
 
Creative and Activities:
Postdoctoral Research Advisor
- Dr. Kyeong-Nam Yu [September 2015 - Present]

PhD Student Thesis Advisor
- Alexander Roth, Chemical engineering [August 2013 - Present]
- Pranav Joshi, Biomedical engineering [December 2013 - Present]
- Parnian Bigdelou, Chemical engineering [August 2015 - Present]
- Gautam Mahajan, Biomedical engineering [August 2015 - Present]

MS Student Thesis Advisor
- Soo-Yeon Kang, Chemical engineering [October 2016 - Present]

Undergraduate Student Research Advisor
- Rushabh R. Patel, Honors student research [June 2017 - Present]
- Stephen Hong, Pre-med research associate [July 2016 - Present]
- Noor Janto, Pre-med research associate [October 2016 - Present]
- Nicolas Lesh, Pre-med research associate [March 2017 - Present]
- Daniel Kim, Pre-med research associate from Brown University [May 2017 - August 2017]
- Mujeeb Wafa, Undergraduate research associate [May 2017 - August 2017]
- Gyu-Young Park, High-school research associate [June 2017 - August 2017]

Undergraduate Student Summer Research Advisor
- Yana Sichkar, Undergraduate summer research [May 2017 - August 2017]
- Stephen Hong, Undergraduate summer research [May 2017 - August 2017]
- Yana Sichkar, Undergraduate summer research [May 2016 - August 2016]
- Emily Serbinowski, Undergraduate summer research [May 2016 - August 2016]
- Yana Sichkar, Undergraduate summer research [May 2015 - August 2015]
- Pratap Lama, Undergraduate summer research [May 2014 - August 2014]

Students Graduated under my Guidance
- Akshata Datar, MS degree, Biomedical engineering [December 2013 - May 2016]
- Stephen Dunn, Honors student research [August 2015 - May 2016]
- Emily Serbinowski, Honors student research [August 2015 - May 2017]
 
Research Interests:
Dr. Lee and his graduate students are developing microarray chip technology in predicting human toxicology. Our research is focused on two main areas:
1) Develop nanoscale 3D human cell printing on a chip for tissue engineering and disease modeling
  - 3D neural stem cell microarrays for developmental toxicology
  - Human liver tissue constructs via layer-by-layer cell printing
  - Tumor micro-tissue constructs with patient cancer cells for personalized cancer therapy
2) Establish high-content imaging (HCI) with 3D-cultured human cells
3) Develop viral gene delivery systems to study individual-dependent, adverse drug responses
4) Multiplexed screening of glycopolymers for modulation of immune cells for cancer therapy
5) Synthesize tunable hydrogels (bioink) for microarray 3D bioprinting
 
Teaching Areas:
- Pharmaceutical assay development (BME 625/725) [Fall 2013] [Fall 2016]
- Biomedical instrumentation (BME 580) [Spring 2014] [Fall 2015] [Fall 2017]
- Drug design and development (BME 694/794) [Fall 2014]
- Chemical reactor design lab (CHE 404) [Spring 2015]
- Chemical reactor design (CHE 404) [Spring 2016] [Spring 2017]
- Chemical process safety (CHE 494/594), Chapters 2 (Toxicology) & 3 (Industrial Hygiene) [Spring 2015]
- 3D Bioprinting (to be developed)
 
Professional Affiliations:
1995-2009 Member, Korean Institute of Chemical Engineers
1997-2001 Member, Japan Institute of Chemical Engineers
2001-2009 Member, American Institute of Chemical Engineers
2001-2010 Member, American Chemical Society
2009-2014 Member, Society of Toxicology
2011-present Member, Biomedical Engineering Society
 
Professional Experience:
1997-1998 International Exchange Student, Tokyo Institute of Technology, Tokyo, Japan
1999-2001 JSPS Postdoctoral Fellow, Department of Chemical Engineering, Tokyo Institute of Technology, Tokyo, Japan
2001-2004 Postdoctoral Research Scientist, Department of Chemical & Biological Engineering, Rensselaer Polytechnic Institute, Troy, NY
2004-2013 Lead/Senior Scientist, Solidus Bioscience, Inc., San Francisco, CA
2013-2016 Consultant, Solidus Biosciences, Inc., San Francisco, CA
2014-present Adjunct Faculty, School of Medicine, Case Western Reserve University, Cleveland, OH
2013-present Assistant Professor, Department of Chemical & Biomedical Engineering, Cleveland State University, Cleveland, OH
2016-present Co-founder and Chief Technology Officer, 3D MicroArray, Inc., Cleveland, OH
 
University Service:
January 2016-present University Research Council
February 2017-present BMES Student Chapter Advisor
August 2013-July 2017 College of Engineering Nominating Committee
August 2014-July 2016 College Faculty Secretary
Jan. 2014-August 2015 AIChE Student Advisor
August 2013-July 2014 Department Secretary
 
Professional Service:
1999-present Journal Referee for AIChE Journal, Biomaterials, Biomedical Microdevices, Bioresource Technology, Biotechnology and Bioengineering, Biotechnology Progress, Carbohydrate Research, Cell Biology and Toxicology, European Polymer Journal, Hepatology, Industrial & Engineering Chemistry Research, Journal of the American Chemical Society (JACS) Communication, Journal of the Brazilian Chemical Society, Journal of Chemical Technology and Biotechnology, Journal of Environmental Management, Journal of Hazardous Materials, Journal of the Science of Food and Agriculture, Polymer International, PLOS One, Scientific Reports, Water Science and Technology
2010-2013 Editorial Board Member, Journal of Drug Metabolism & Toxicology (Open Access)
2015-present Editorial Board Member, Journal of Mushrooms
2015-2015 Guest Editor of BioMed Research International, Special Issue on Microtechnologies for High-Throughput, High-Content Screening: Applications in Drug Discovery and Biomedical Research
2010-present NIH Peer Review Committee (2010/12 ZES1 RAM-D, 2013/08 ZES1 SET-J, 2014/10 ZRG1 IMST-L, 2015/05 ZAT1 HS-P, 2015/08 ZES1 SET-J, 2016/01 ZTR1 DPI-9, 2016/10 ZTR1 DPI-7, 2017/09 ZTR1 DPI-9)
 
Research Grants:
14. Lee, M.Y. (principal investigator), Chip-based, miniaturized 3D bioprinting for chemical toxicity assessment, 2017 I-Corps@Ohio MedTech Cohort, Ohio Department of Higher Education (07/01/17 - 06/30/18)
13. Lee, M.Y. (principal investigator), Microarray 3D bioprinting for toxicology assessment, Cleveland state university (CSU), Faculty innovation fund (09/01/2016 - 08/31/2017)
12. Lee, M.Y. (principal investigator) and Gerald, R. (co-investigator), Transform Tox Testing Challenge: Innovating for Metabolism, Stage I, funded US EPA and NIH (07/08/16 - 12/31/16)
11. Lee, M.Y. (principal investigator) and Kothapalli, C.R. (co-investigator), Mechanistic study of developmental neurotoxicity on 3D cultured stem cell microarrays, National Institute of Health (NIH)-R01, Grant number R01ES025779 (07/01/2015 - 06/30/2019)
10. Lee, M.Y. (principal investigator), Cell-based microarray biochip platforms for predictive human toxicology, Cleveland state university (CSU), Faculty research development (09/01/2014 - 08/31/2015)
9. Lee, M.Y. (principal investigator) and Dordick, J.S. (co-investigator), TeamChip for high-throughput, predictive human metabolism and toxicology, Phase II National Institute of Health (NIH)-Small business technology transfer (STTR) program, Grant number 2R42 ES018022-02 (02/01/2012 - 01/31/2014)
8. Lee, M.Y. (principal investigator), Development and feasibility testing for the transfected enzyme and metabolism (Team) chip, Samsung Electro-mechanics Co. (01/01/2010 - 12/31/2011)
7. Lee, M.Y. (principal investigator), Optimization of the DataChip and MetaChip for commercialization, Samsung Electro-mechanics Co. (01/01/2010 - 12/31/2011)
6. Lee, M.Y. (principal investigator) and Dordick, J.S. (co-investigator), TeamChip for high-throughput, predictive human metabolism and toxicology, Phase I National Institute of Health (NIH)-Small business technology transfer (STTR) program, Grant number 1R41 ES018022-01 (02/01/2010 - 01/31/2011)
5. Lee, M.Y. (principal investigator), Clark, D.S. (co-investigator) and Dordick , J.S. (co-investigator),  Development of a lead optimization chip for drug discovery, Phase II National Science Foundation (NSF)-Small business technology transfer (STTR) program, Grant number 0923853 (08/01/2009 - 07/31/2011)
4. Lee, M.Y. (principal investigator) and Clark, D.S. (co-investigator), A high-throughput human metabolic stability assay chip for early-stage drug discovery, Phase I National Institute of Health (NIH)-Small business technology transfer (STTR) program, Grant number 1R41GM080877-01A1 (02/05/2008 - 02/04/2010)
3. Lee, M.Y. (principal investigator) and Clark, D.S. (co-investigator), Development of a lead optimization chip for drug discovery, Phase I National Science Foundation (NSF)-Small business technology transfer (STTR) program, Grant number 0711708 (07/01/2007 - 06/30/2008)