Sailen Barik, PhD
 Title: Professor
Professor, Department of BGES
 Dept: Biology, Geology, Environmental Science
 Office: SR 263
 Phone: 216-875-9824
 Fax: 216-687-6972
 Email: S.BARIK@csuohio.edu
 Web: http://www.csuohio.edu/sciences/grhd.html
 Address: 2121 Euclid Ave. SR 263, Cleveland, OH 44115

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Research Keywords:
Respiratory syncytial virus (RSV); Toxoplasma gondii; RNA interference; Argonaute.
 
Education:
Ph.D., Biochemistry, Bose Institute, Calcutta, 1982
M.S., Biochemistry, Calcutta University, 1976
 
Brief Bio:
Name: SAILEN BARIK
Citizenship: USA

Education:

B. Sc. (1972) Honors in Chemistry, Physics, Math; Calcutta University, India
M. Sc. (1976) Biochemistry; Calcutta University, India
Ph. D. (1982) Biochemistry; Bose Institute, Calcutta, India

Employment:

1981-82 Postdoctoral Associate, Division of Biophysics, Indian Institute of Chemical Biology, Calcutta, India
1982-86 Postdoctoral Fellow, Dept. of Microbiology, University of Connecticut Health Center, Farmington, Connecticut
1986-88 Research Associate, Department of Microbiology, University of Connecticut Health Center, Farmington, Connecticut
1989-92 Project Scientist, Department of Molecular Biology, Cleveland Clinic, Cleveland, Ohio
1992-94 Assistant Staff in above
1994-99 Assistant Professor; Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama
1999-2003 Associate Professor, in above
2003-2010 Professor, in above
2002-2010 Joint appointment in Department of Microbiology and Immunology
2002-2010 Member, Lions-USA Eye Research Center
2004-2010 Member, Center for Lung Biology
2010-present Director, Center for GRHD; Professor, Department of BGES, CSU
2011-present Adjunct faculty, Department of Molecular Genetics, Cleveland Clinic, Ohio
 
Honors and Awards:
1965-1969 Valedictorian
1969 15th in State School Board Final Exam (out of about 150,000 students)
1969-1971 National (Merit) Scholar, Government of India
1974 Honors in Chemistry, Calcutta University
1976 Ranked 2nd in order of merit in M.Sc., Calcutta University;
1976-1981 Junior and Senior Research Fellowships, Department of Science and Technology, Government of India
1982 Recipient, Lady Tata Memorial Research Fellowship
1987 Research Fellow Award, University of Connecticut Health Center, CT
1995-present Who's Who in America; Who's Who in Science and Engineering; Who's Who in the South-East, etc.
1999 & 2002 Featured in newsletter "The Beat", USA
2000 Burroughs-Wellcome Award for "New Initiatives in Malaria"
2002 President, University Lion's Club
2004 Invited speaker, Keystone Symposium on siRNA and miRNA
2004 Keynote speaker, Australian Society of Microbiology Annual Meeting, Sydney
 
Creative and Activities:
Intellectual Property:

1) US Patent 7,592,322: "RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof ".

Our research in RNA interference (RNAi), particularly in antiviral RNAi and nasal delivery, has received international acclaim. Our first paper in this area was the "All-time most accessed paper" (Click here: http://www.biomedcentral.com/bmcmicrobiol/mostviewedalltime/) for many years. Our second paper, which came out in Nature Medicine, forms the basis of the Patent and our Licensing Agreement with Alnylam (Cambridge, MA), currently the largest RNAi Company. Of note, the Scientific Advisory Board of Alnylam includes major leaders in the RNA area (Bartel, Tuschl, Harlow, Sharp, Schimmel, Zamore) (Click here for the joint Alnylam-USA Press Release:
http://phoenix.corporate-ir.net/phoenix.zhtml?c=148005&p=irol-newsArticle2&ID=658545&highlight=). In fact, this is now a top-priority project in Alnylam's drug development pipeline and has successfully completed Phase 2 clinical trial. If eventually approved, this will be the first antiviral RNAi in the pharmacy.
This work has been featured on NOVA Science Now (in PBS) as one of the landmark discoveries in Medicine (Click here: http://www.pbs.org/wgbh/nova/sciencenow/3210/02-cure.html

2) US Patent 5,831,069: "Antisense oligonucleotides against nonstructural proteins NS1 and NS2 of respiratory syncytial virus and uses thereof".
 
Research Interests:
Suppression of innate immunity by RNA viruses; Interactions between host and Toxoplasma gondii; RNA interference in lower eukaryotes.
 
Teaching Areas:
By Departmental assignment; Expertise in Virology, Biochemistry, Signal Transduction.

Current (in CSU; Pre-CSU teaching not shown):
Fall 2012: BIO 688/888, 1 Credit: Seminar in Virology.
Spring 2013: BIO 688/888, 1 Credit: Research seminar.
 
Professional Experience:
Scientific Founder: Sirnamics Ltd., MD, USA.
Book: Editor, "RNAi: Design and Application", Human Press, NJ, USA (2008).
Journal Editorial: Associate Editor, BMC Microbiology.
Guest Editor, Molecular and Cellular Pharmacology, 2012.
Conference: Organizer and Host of "Southeastern Society for Parasitologists Annual Meeting", Mobile, AL (2003).
Legal: Expert witness for the Mobile County assistant DA's office in an HIV trial (2002).
 
Research Grants:
Current:
NIH: "Nikon A1RSI Confocal Microscope"; Period 05/01/12-04/31/13.

Past:
NIH: "Discovery of novel inhibitors of Hsp90/TRAP1" (SBIR Phase-1) (2010-2012).
Phase-2 being discussed.
Michael J. Fox foundation-Therapeutic Development Initiative Program: "Novel, selective and potent brain-penetrating small molecule inhibitors of cytosolic Hsp90".
NIH (NIAID): "Mechanisms of RNA virus-host interaction"; R01 (2005-2011).
NSF-EPSCoR: Effect of nonstructural proteins 1 & 2 (NS1 & NS2) of the human respiratory syncytial virus on host interferon response" (GRSP award; 2007-2009).
NSF-EPSCoR: "Association of host organelles with intracellular parasite Toxoplasma gondii: Mechanisms and significance" (2008-2010)
NIH (NEI): "Interactions between ocular tissue and RSV"; R01 (2002-2005).
NIH (NIAID): "Reversible phosphorylation in Apicomplexans"; R01 (2000-2005)
Burroughs-Wellcome Foundation Award: "New Initiatives in Malaria Research" (1999-2001).
NIH (NIAID): "Gene expression of human respiratory syncytial virus" (1994-2000).
American Cancer Society (1992-1994).
American Heart Association (1991-1992)
American Cancer Society (1990-1991).