Xue-Long Sun, Ph.D.
X_SUN55.jpg
 Title: Professor
 Dept: Chemistry
 Office: SI 313
 Phone: 216-687-3919
 Fax: 216-687-9289
 Email: X.SUN55@csuohio.edu
 Web: http://academic.csuohio.edu/sunlab
 Address: 2121 Euclid Ave. SI 313, Cleveland, OH 44115

Courses Taught

Publications


Faculty Only:
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Research Keywords:
Antithrombtic and Antiviral Drugs, Drug Delivery, Glycan Microarray, Biosensor, Glycomics, Cellular Chemistry, Chemical Biology, Biopharmaceutical Chemistry
 
Education:
B.S., Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, China, 1988
M.S., Pharmaceutical Chemistry, Kitasato University School of Pharmacy, Tokyo, Japan, 1994
Ph.D., Pharmaceutical Chemistry, Kitasato University School of Pharmacy, Tokyo, Japan, 1997
Postdoctoral Fellow, Glycotechnology and Synthetic Cellular Chemistry, RIKEN Institute, Wako, Japan, 2000
Postdoctoral Fellow, Surgery/Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, 2002
 
Brief Bio:
After trained in pharmaceutical sciences, Dr. Sun has experienced a wide range of pharmaceutical and biomedical researches. First, he had worked on anti-influenza agent (Medicinal Chemistry) at RIKEN Institute (Japan) as a basic science special research fellow working with Dr.s Chi-Huey Wong, Osamu Kanie and Yukishige Ito, then worked on antithrombotic biomaterials (Biomedical Engineering) at Emory University School of Medicine as a NIH-funded research fellow working with Dr. Elliot L. Chaikof, Since 2002, Dr. Sun has started his academic career at Emory University School of Medicine first and Cleveland State University now as a Full Professor of Chemistry (primary) and Biomedical Engineering (secondary) working on Pharmaceutical Chemistry, Biopharmaceutical Chemistry, Bioanalytical Chemistry, Chemical Biology, and Biomaterial Chemistry research.
 
Honors and Awards:
2014 Fellow of the American Heart Association (FAHA), elected by the Council on Basic Cardiovascular Sciences (BCVS) of AHA.
2014 American Heart Association Grant-in-Aid Research Grant Award
2014 Faculty Merit Recognition Award of Research, Cleveland State University
2014 Distinguish Faculty and Staff Award, Chinese American Faculty and Staff Association (CAFSA), Cleveland State University
2013 Faculty Merit Recognition Award of Research, Cleveland State University
2013 External advisory panel for Metabolomics Resource grant programs, NIH NHLBI
2012 Distinguished Faculty Award for Research, Cleveland State University
2012 Faculty Merit Recognition Award of Research, Cleveland State University
2012 Faculty Research Development Grant Award, Cleveland State University
2011 NSF MRI Grant Award for NMR Acquisition at Cleveland State University
2011 Faculty Merit Recognition Award of Research, Cleveland State University
2010 Outstanding Research Award, College of Science, Cleveland State University, Cleveland, Ohio
2010 NIH RO1 Grant Award from NHLBI
2010 Guest Editor of a Special Issue of Carbohydrate Recognition and Applications for Medicinal Research Reviews (Wiley InterScience), 2010, Volume 30 Issue 2
2007 Faculty Research Development Grant Award, Cleveland State University
2007 American Health Assistance Foundation Research Grant Award
2005 American Heart Association Beginning-in-Aid Research Grant Award
2003 Emory University Research Committee Research Grant Award
1997 RIKEN Basic Science Special Researcher Award (From STA of the Japanese Government,1997-2000)
1992 Kitasato University Graduate Scholarship, Tokyo, Japan (1992-1997)
1987 Outstanding Senior Honor, ShenYang Pharmaceutical University, ShenYang, China
 
Research Interests:
The main research interests in Dr. Sun' group are in the following three areas:
  * Functional glyco-affinity ligand engineering: For proteomics and glycomics, pathogen and biomarker identification, antiviral drug and targeted drug delivery applications.
  * Cytomimetic antithrombotics: To explore vascular pathological and surgical interventional sites-local/targeted antithrombotics.
  * Biological and cellular chemistry: To develop site-specific/chemo- and bio-orthogonal and live cell compatible approaches for biomolecules, biomaterials and cells modification and functionalization.
 
Teaching Areas:
Organic Chemistry
Medicinal Chemistry
Pharmacology
 
Professional Affiliations:
American Chemical Society
American Association of Pharmaceutical Scientists
The Society of Glycobiology
American Heart Association
American Society of Mass Spectrometry
 
Professional Experience:
2013-2014 Visiting Professor, Department of Pathology, Case Western Reserve University, Cleveland, OH
2012- Adjunct Professor, Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH
2012- Professor, Department of Chemistry, Cleveland State University, Cleveland, OH
2012-2009 Associate Professor, Department of Chemistry, Cleveland State University, Cleveland, OH
2009- Member of Center for Gene Regulation in Health and Disease (GRHD), Cleveland State University, Cleveland, OH.
2007- Adjunct Staff, Department of Molecular Cardiology, the Lerner Research Institute, Cleveland Clinic, Cleveland, OH.
2009-2006 Assistant Professor, Department of Chemistry, Cleveland State University, Cleveland, OH
2006-2002 Assistant Professor, Department of Surgery and Biomedical Engineering, Emory University School of Medicine, Atlanta, GA.
2002-2000 NIH-Funded Research Fellow, Department of Surgery, Emory University School of Medicine, Atlanta, GA.
2000-1997 Basic Sciences Special Research Fellow, Laboratory of Glycotechnology & Synthetic Cellular Chemistry Laboratory, RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
1991-1989 Research Assistant, Department of Medicinal and Natural Product Chemistry, ShenYang Pharmaceutical University, ShenYang, China.
 
Professional Service:
Executive Editor (Peer Reviewed Journal)
2010- Journal of Glycomics and Lipidomics (OMICS Publishing Group)

Editorial Board Member (Peer Reviewed Journal)
2012- Medicinal Chemistry (OMICS Publishing Group)
2011- International Journal of Organic Chemistry (Scientific Research Publishing Group)
2011- World Journal of Pharmacology (Baishideng Publishing Group)
2008- Adaptation and Treatment (Dove Medical Press)

Guest Editor Invited (Peer Reviewed Journal)
2010 Medicinal Research Reviews (Wiley InterScience), Special Issue for Carbohydrate Recognition and Applications, 2010, 30, 2.

Organizer of Professional Conference
Organizing Committee Member for the 2013 International Conference on Metabolomics & Systems Biology (April 8-10, 2013, Chicago, USA)
Organizing Committee Member for the 2012 International Conference on Metabolomics & Systems Biology (February 20-22, 2012, San Francisco, USA)
Organizer/Host of the 2010 Cleveland Symposium of Pharmaceutical Sciences (about 50 attendees, April 30, 2010, Cleveland, Ohio).
Organizer/Host of 4th Midwest Carbohydrate and Glycobiology Symposium (72 attendees, October 3-4 30, 2008, Cleveland, Ohio).

Research Proposal Reviewer
NIH: 2012, 2009
AHA: 2009, 2008, 2007
NSFC: 2014, 2009, 2008, 2007
 
Research Grants:
Active
Title: Recombinant Thrombomodulin Glycoconjugate and Its Antithrombotic Activity
Agency: American Heart Association
Role: Principle Investigator
Type: Grant-in-Aid, Period: 2014-2016

Title: MRI: Acquisition of an integrated atomic force microscope/Inverted optical microscope
Agency: National Science Foundation
Role: Co-Investigator (PI: Chandrasekhar Kothapalli)
Type: MRI, Period: 2013-/2016

Title: MRI: Acquisition of 400 MHz NMR Spectrometer
Role: Principle Investigator (CO-PI: Nolan Holland, Bin Su, and John Masnovi)
Agency: National Science Foundation
Type: MRI, Period: 2011-014

Title: Recombinant and Chemo-/Bio-Orthogonal Synthesis of Liposomal Thrombomodulin
Role: Principle Investigator
Agency: National Institute of Health
Type: R01, Period: 2010-2014

Completed
Title: Fabrication and Characterization of Cell Membrane Mimetic System
Agency: Cleveland State University
Role: Principle Investigator
Type: Undergraduate Summer Research Grant, Period: 2014

Title: Immobilized Cell Membrane Mimetic System for Pharmaceutical and Bioanalytical Applications
Role: Principle Investigator
Agency: Cleveland State University,
Type: Faculty Research Development Grant, Period: 2012-2013

Title: Synthesis of Bio-Inspired Thrombomodulin Conjugatesa Novel Anithrombotic Agents
Role: Principle Investigat
Agency: Cleveland State University,
Type: Undergraduate Summer Research Grant, Period: 2012

Title: On-Site Antithrombotic Glycoprotein
Role: Principle Investigator (Co-PI: Q. Y. Wu)
Agency: The Ohio Department of Ohio Board Regents
Type: Ohio Research Scholars Program, Period: 2010-2012

Title: Glyco-Engineering of Recombinant Antithrombotic Protein
Agency: Cleveland State University,
Type: Undergraduate Summer Research Grant, Period: 2011-2011

Title: Synthesis and Characterization of Antithrombotic Protein Conjugates
Agency: Cleveland State University,
Type: Undergraduate Summer Research Grant, Period: 2010

Title: Thrombogenic Site-Directed Antithrombotics
Role: Principle Investigator
Agency: American Health Assistance Foundation
Type: Research Grant, Period: 2007-2010

Title: Synthesis of Antithrombotic Glycoprotein Conjugates
Role: Principle Investigator
Agency: Cleveland State University
Type: Undergraduate Research Grant, Period: 2009

Title: Universal Capture Array for the Discovery of Biomarker of Atherosclerosis
Role: Principle Investigator
Agency: Cleveland State University
Type: Faculty Research Grant, Period: 2007-2009

Title: Site-Targeted Liposomal Antithrombotic and Antiinflammatory Agent
Role: Principle Investigator
Agency: American Heart Association
Type: Beginning-in-Aid, Period: 2005-2007

Title: Site-Specific Antithrombotics
Role: Principle Investigator
Agency: Emory University
Type: Faculty Research Fund, Period: 2004-2005

Title: Antithrombogenic Membrane-Mimetic Assemblies
Role: Co-Investigator (PI: E. Chaikof)
Agency: National Inst