Kailash Gulshan
k_gulshan.jpg
 Title: Assistant Professor
 Dept: Biological, Geological and Environmental Sciences
 Office: SR 260
 Phone: 216-687-2409
 Email: k.gulshan@csuohio.edu
 Address: 2121 Euclid Ave. SR 260, Cleveland, OH 44115

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Research Keywords:
Cholesterol, HDL, LDL, Sphingolipids, Ceramides, Atherosclerosis, Cardiovascular disease (CVD), PIP2, Autophagy, Inflammation, Lung cancer, NLRP3 inflammasome, Interleukins, IL-1b, Gasdermin D.
 
Education:
Ph.D., Biotechnology, Jawaharlal Nehru University, New Delhi, 2004
 
Brief Bio:
My research is focused on the role of inflammation in cardiovascular disease (CVD)and lung cancer. In the past several years, I described the role of free cholesterol in inducing autophagy and sphingomyelin biosynthesis in macrophages (PNAS 2015, Autophagy 2015). I also discovered a novel role for a minor phospholipid PIP2 in HDL biogenesis, determining that PIP2 is the lipid recognized by apoA1 in ABCA1-expressing cells, and identifying ABCA1 as a first known PIP2 floppase(Circulation Research 2016). We identified novel anti-atherosclerotic activities of the anti-protozoan drug Miltefosine (Scientific Reports, June 2019). More recently, we demonstrated role of N-terminal region of lipoprotein apoA1 in HDL biogenesis (PLoS One, January 2020) and how HDL promotes prostate cancer progression (JBC, May 2020).

In addition to NIH RO1 funding to study role of PIP2 in atherosclerosis and
inflammation, I have obtained a Case Comprehensive Cancer Center pilot funding from Case Western University to study role of inflammation in lung cancer progression and metastasis.
I also contribute to atherosclerosis and inflammation field by performing peer review for scientific journals such as JAHA, Atherosclerosis, Autophagy, Cytokine, Clinical and Experimental Allergy,Inflammatory Bowel Diseases, Cardiovascular & Hematological Disorders-Drug Targets, Drug Design, Development and Therapy, Journal of Hepatic Medicine: Evidence and Research, and served as an editor for Biomarkers of Cardiovascular Diseases; Disease Markers.
In addition to research, I have experience of multiple years in teaching Microbiology with Lab, Pathophysiology, and carbohydrate metabolism course to medical and PhD. students
 
Honors and Awards:
Elsa Albretch award for best paper, 2020, Cardiovascular & Metabolic Sciences, Cleveland Clinic.
* Elsa Albretch award for best paper, 2017, Cellular & Molecular Medicine, Cleveland Clinic.
* Best poster award, Gordon Research Conference of lipoprotein metabolism 2016.
* Best poster award, Cleveland Clinic Institute research day 2016 (1st prize).
* Best poster award, Lerner Research Institute research day 2016 (1st prize).
* Best poster award, Lerner Research Institute research day 2015 (2nd prize).
* Best poster award, Cleveland Clinic research day 2012 (1st prize).
 
Research Interests:
1) Role of Sphingolipids in Cardiovascular disease.

2) Autophagy in heart disease and cancer.

3) Role of inflammation in heart disease.

4) Role of inflammation in lung cancer.
 
Teaching Areas:
Microbiology, Pathophysiology, Biochemistry.
 
Professional Affiliations:
American Heart Association (AHA)
 
Professional Experience:
2002-2005: Postdoctoral fellow, University of Iowa, Iowa-city, IA.
2005-2011: Assistant Research Scientist, University of Iowa, Iowa-city, IA.
2011- 2015: Research Associate, Lerner Research Institute, Cleveland Clinic, OH
2015-2016: Project Scientist, Lerner Research Institute, Cleveland Clinic, OH
2016-2020: Adjunct Assistant Professor of Molecular Medicine, Cleveland Clinic, OH
 
Community Service:
Judging scientific posters/events:

Annual Concept Science & Engineering Fair (CONSEF), Cleveland (2014-2017).

NEOSEF, Cleveland State University (2016).

Solon Middle School Science Fair, Solon, OH (2017)
 
Research Grants:
Active:

1) NIH-NHLBI-RO1: (K Gulshan, PI) (04/01/2020-03/31/2024)
Title: Phosphatidylinositol metabolism and trafficking in atherosclerosis and inflammation.

2) Case Comprehensive Cancer Center: (K Gulshan, PI) (06/2020-06/2021)
Title: Role of PIP2 and Gasdermin D in Lung Cancer Progression and Metastasis.

Completed:

1) American Heart Association Scientist Development Grant SDG25710128 (K Gulshan, PI) (7/1/2015-6/30/2019)
Title: Mechanisms of cellular lipid homeostasis and nascent HDL formation.

2) NCAI-CC-2016-I-Corps-SD (K Gulshan, PI) (6/1/2016-7/31/2016).