Publications:

Elagooz R, Dhara AR, Gott RM, Sarah AE, White RA, Ghosh AA, Ganguly S, Man Y, Owusu-Ansa A, Mian OY, Gurkan UA, Komar A, Ramamoorthy M, Gnanapragasam MN. PUM1 mediates the post-transcriptional regulation of human fetal hemoglobin. Blood Advances. 2022 Jun 6; doi: 10.1182/bloodadvances.2021006730. Epub ahead of print. PMID: 35667093.

Mukherjee M, Xue L, Planutis A, Gnanapragasam MN, Chess A, Bieker JJ. EKLF/KLF1 expression defines a unique macrophage subset during mouse erythropoiesis. Elife. 2021 Feb 11;10:e61070.¿¿¿¿¿¿¿

Gnanapragasam MN, Crispino JD, Ali AM, Weinberg R, Hoffman R, Raza A, Bieker JJ. Survey and evaluation of mutations in the human KLF1 transcription unit. Sci Rep. 2018 Apr 26;8(1):6587.

Gnanapragasam MN, Bieker JJ. Orchestration of late events in erythropoiesis by KLF1/EKLF. Curr Opin Hematol. 2017 May;24(3):183-190.

Gnanapragasam MN, McGrath KE, Catherman S, Xue L, Palis J, Bieker JJ. EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation. Blood. 2016 Sep 22;128(12):1631-41. (Highlighted in Hematopoiesis News).

Liang R, Campreciós G, Kou Y, McGrath K, Nowak R, Catherman S, Bigarella CL, Rimmelé P, Zhang X, Gnanapragasam MN, Bieker JJ, Papatsenko D, Ma'ayan A, Bresnick E, Fowler V, Palis J, Ghaffari S. A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. PLoS Genet. 2015 Oct 9;11(10).

*Yien YY, *Gnanapragasam MN, Gupta R, Rivella S, Bieker JJ. Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues. Exp Hematol. 2015 Jan;43(1):65-70. (*Authors contributed equally).

Xue L, Galdass M, Gnanapragasam MN, Manwani D, Bieker JJ. Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche. Development. 2014 Jun;141(11):2245-54.

Jaffray JA, Mitchell WB, Gnanapragasam MN, Seshan SV, Guo X, Westhoff CM, Bieker JJ, Manwani D. Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm. Blood Cells Mol Dis. 2013 Aug;51(2):71-5

Amaya M, Desai M, Gnanapragasam MN, Wang SZ, Zu Zhu S, Williams DC Jr, Ginder GD. Mi2ß-mediated silencing of the fetal ¿-globin gene in adult erythroid cells. Blood. 2013 Apr 25;121(17):3493-501.

Mian OY, Wang SZ, Zhu SZ, Gnanapragasam MN, Graham LJ, Bear HD, Ginder GD. Methyl Binding Domain Protein 2 (MBD2) Dependent Proliferation and Survival of Breast Cancer Cells. Mol Cancer Res. 2011;9(8):1152-62.

Gnanapragasam MN, Scarsdale JN, Amaya ML, Webb HD, Desai MA, Walavalkar NM, Wang SZ, Zu Zhu S, Ginder GD, Williams DC Jr. p66Alpha-MBD2 coiled-coil interaction and recruitment of Mi-2 are critical for globin gene silencing by the MBD2-NuRD complex. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7487-92.

Rupon JW, Wang SZ, Gnanapragasam M, Labropoulos S, Ginder GD. MBD2 contributes to developmental silencing of the human ¿-globin gene. Blood Cells Mol Dis. 2011 Mar 15;46(3):212-9.

Ginder GD, Gnanapragasam MN, Mian OY. The role of the epigenetic signal, DNA methylation, in gene regulation during erythroid development. Curr Top Dev Biol. 2008;82:85-116.