Jacqueline Vitali, Ph.D.
 Title: Assoc Prof Physics and BGES
 Dept: Physics
 Office: SI 122
 Phone: 216-687-2431
 Email: J.VITALI@csuohio.edu
 Address: 2121 Euclid Ave. SI 122, Cleveland, OH 44115

Courses Taught


Faculty Only:
Update Profile

Research Keywords:
Crystallography, x-ray Diffraction, Proteins, Drug discovery, Extremophiles, Archaeal Proteins, Proteins of the Pyrimidine Pathway, Ornithine Transcarbamoylase, Aspartate Transcarbamoylase, Dihydroorotase Regulatory Enzymes
Ph.D., Biophysics, State University of New York at Buffalo
B.S., Physics, University of Athens
Brief Bio:
will come soon
Honors and Awards:
Merit Recognition Award (research and service), 2020 (CSU).  Amount: $1K.
Graduate Faculty Research support (for ACA 2018 meeting), 2018 (CSU).  Amount: $800
Graduate Faculty Research support (for publication charges), 2017 (CSU).  Amount:  $750.
Graduate Faculty Research support (for IUCR 2017 congress), 2017 (CSU).  Amount $1250.  
Graduate Faculty Travel Award (for ACA 2015 meeting), 2015 (CSU). Amount: $800.
Graduate Faculty Travel Award (for IUCR 2014 meeting), 2014 (CSU).  Amount: $1.2K.
Merit Recognition Award (research and teaching), 2014 (CSU).  Amount: $1K.
Creative and Activities:
Very recent only --

Vitali, Nix, Newman and Colaneri
Crystal Structure of Methanococcus jannaschii Dihydroorotase
Proteins (2022)
Research Interests:
      My research involves the structural analysis of macromolecules by X-ray diffraction.  Such studies provide direct and unambiguous information regarding all the details of the three-dimentional atomic arrangement of these molecules.  This information is necessary in order to understand their properties and function.
      My current efforts focus in acquiring a better understanding of de novo pyrimidine biosynthesis at the molecular level.  In this connection, I have determined the structure of the catalytic trimer of the enzyme Aspartate transcarbamoylase from the hyperthermophilic and barophilic archaeon M.jannaschii in two crystal forms.  This research gave insight into the strategies for thermostabilization of this important enzyme.  The most intriguing feature of these structures is the association of crystallographically independent subunits in pairs into a novel staggered complex with a short inter-trimer distance of 33.8 Å. This novel staggered arrangement may be present in the holoenzyme in vivo in the presence of the regulatory subunits.  In order to gain more insight into the mechanism of catalysis we co-crystallize the enzyme with substrate analogs.
      Past research includes complexes of bovine thrombin with inhibitors including the leech protein hirudin, one Fab fragment, S100b, the EF-Tu-Ts complex, pectin lyase B, histidine decarboxylase, the Gly121Tyr mutant of ornithine decarboxylase from Lactobacillus 30a, the UP1 fragment of hnRNP A1, myoglobin, and insulin.
Postdoctoral fellow:
Aditya Singh, Ph.D., 10/2007-3/2009
Teaching Areas:
Algebra and Calculus based Physics

Undergraduate Research Students
Oana Sipos, 1/2004 - 5/2007 (Physics, NIH grant support)
Nermina Covic, 7/2005 - 11/2006 (Physics, NIH grant support)
Khadidja Benmerzouga, 4/2007 - 9/2009 (Physics, in part NIH grant support and in part Engaged Learning)
Frank Marealle, 3/2008 - 5/2008 (Physics, NIH grant support)
Jonathan Allen, 7/2008 - 9/2008 (Physics, Engaged Learning)
Nura Orra, 1/2009 - 9/2009 (Physics, Engaged Learning)
Charlie Dorflinger, 6/2010 - 9/2010 (Physics, Engaged Learning)
Elissar Daher, 5/2012 - 12/2013 (BGES, Honors)
Joseph Skladany, 1/2014 - 5/2014 (Physics)
Amy Dadisman, 5/2017 - 8/2017 (BGES USRA)    
Haley Newman, 1/2018-5/2019.  (BGES)
Ryan Godin, 5/2018 - 8/2018 and 5/2019 -8/2019 (Physics USRA)
Angelica Houston, 1/2019-5/2019 (BGES)
Mohamed Alsabony 6/2019-8/2019 (Physics USRA)

Graduate Research Students
Dan Meleason, Fall 2008 (Physics, NIH grant support)

Graduate Student Committees
Baixi Su-Alexander (Electrical Engineering, D.E. 5/2008):
Ozge Can (Chemical and Biomedical Engineering, D.E. 12/2008):
Boo Seok Yun (Clinical Chemistry, Ph.D. program)
William Martin (Clinical Chemistry, Ph.D. 12/2018)
Anup S. Mathew (Electrical Engineering, D.E. program)
Professional Affiliations:
American Crystallographic Association
Pittsburgh Diffraction Society
Microscopy Society of Northeastern Ohio
University Service:
Minority Affairs Committee, 8/16 - present
Academic Technology Committee, 5/13 - 7/14
COSHP nominating committee, 9/12 - present; Chair, 9/15 - present
COSHP steering at large member, 9/15 - 7/16
Environmental Health and Safety Advisory Board, 9/12-9/13
Physics Peer Review Committee, 1/12 - present
Equal Opportunity Hearing Panel, 10/11 - 8/16
Curriculum Committee in Medical Physics, 9/11 - present; minutes taker
Graduate Grade Dispute Committee, 8/09 - 10/11                  
Graduate Faculty Review Committee, 8/07 - 8/09
Graduate Admissions and Standards Committee, 8/05 - 8/07
Steering Committee in Medical Physics, 1/03 - present; minutes taker
Physics Faculty Search Committee, 2003 - 2004
Physics Faculty Search Committee, 2005 - 2006
Physics Faculty Search Committee, 2008 - 2009
Physics Visiting Faculty Search Committee, 4/12 - 5/12
Physics Faculty Search Committee, 2012-2013
Physics Faculty Search Committee, 2013-2014
Physics Lecturer Search Committee, 2013-2014, Co-chair
Medical Physics Faculty Search Committee, 2016-2017
Physics Chair Search Committee, Fall 2016
Physics Assistant Lecturer Search Committee, 2017
Professional Service:
      Reviewer for Acta Crystallographica, Biochemistry, Bioorganic and Medicinal Chemistry, Accounts of Chemical Research, Archives of Biochemistry and Biophysics.
      Chair of poster session on Biological Macromolecules in the 1994 Amer. Cryst. Assoc. Annual Meeting at Atlanta, Georgia.
      Chair of the Theory Session of Contributed Papers in the "2005 World Year of Physics Einstein Centennial: From Brownian Motion to the Physics of Complexity" meeting of the Ohio Section of the American Physical Society at Cleveland State University, Cleveland, Ohio (10/15/2005).
      Judge for the Mitegen and Society of Physics Students Undergraduate Poster Prize at the 2015 American Crystallographic Association meeting in Philadelphia, PA.
      Chair of the Theoretical and Computational Session (E4) of Contributed Papers in the "Physics in Biology and Medicine" Fall 2015 meeting of the Ohio Section of the American Physical Society at Cleveland State University, Cleveland, Ohio (10/17/2015).
Research Grants:
      Following the Dihydroorotase reaction with pH in Methanococcus jannaschii.  Undergraduate Summer Research Award (USRA), 5/15/20-8/30/21 (CSU).  Amount: $5040.
      Crystallization of Dihydroorotase from Methanococcus jannaschii.  Undergraduate Summer Research Award (USRA), 5/15/19-8/31/19 (CSU).  Amount: $4500.
      Crystallization of an Archaeal Dihydroorotase.  Undergraduate Summer Research Award (USRA), 5/15/18-8/31/18 (CSU).  Amount: $5030
      Structural Studies of an Archaeal Dihydroorotase.  Undergraduate Summer Research Award (USRA), 5/17-8/17 (CSU).  Amount $4830.
      Structural Studies of an Aspartate Transcarbamoylase.  Faculty Scholarship Initiative; 9/14-3/16 (CSU).  Amount: $5k.  
      Structural Studies of an Aspartate Transcarbamoylase.  Faculty Research Development Award; 7/09-12/10 (CSU). Amount: $15K.
      Structural Studies of the Pyrimidine Pathway.  NIH R15 grant; 9/04-9/09 (CSU). Amount: $210K.
      Engaged Learning Undergraduate Program; summer 2010, summer 2009, summer 2008; ~ $4K per summer, Office of the Provost, CSU.
      Startup Package Fund (CSU)
      National Research Service Award from institutional training grant in experimental hematology; 9/92-7/94.  (WSU)
      Determination of the Crystal Structure of the S100b Protein.  Cystic Fibrosis Foundation Research Fellowship; 5/87-5/89. (UVa)

Research grants to students
      Haley Newman: Undergraduate Research Award (URA) (CSU); spring 2019.  Amount: $1000.