Roman V Kondratov
 Title: AVP Research & Professor
 Dept: Biological, Geological and Environmental Sciences
 Office: SR 270
 Phone: 216-687-5171
 Address: 2121 Euclid Ave. SR 270, Cleveland, OH 44115

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Research Keywords:
aging, circadian clock, circadian system, circadian rhythms, stem cells, metabolism, caloric restriction, dietary restriction, nutrient response, osteoporosis, genotoxic stress, reactive oxygen species, circadian behavior
Ph.D., Molecular Biology, Enhelhardt Institute of Molecular Biology
Brief Bio:
Dr. Kondratov obtained his M.S. in Physics and Mathematics from Moscow Institute of Physics and Technology, his PhD in Molecular and Cellular Biology from Enhelhardt Institute of Molecular Biology (with Dr. Peter Chumakov), and has post-graduate training in University of Illinois at Chicago (with Dr. Andrei Gudkov) and Cleveland Clinic Foundation (with Dr. Marina Antoch). He joined Cleveland State University in 2006.
Research Interests:
Our laboratory were instrumental in establishing a connection between the circadian clock and aging.We use in vitro to in vivo systems, and different techniques and approaches in order to uncover the molecular mechanisms of the circadian control of aging.

"The circadian system" or the circadian clock is a internal genetically determined time keeping mechanism, which was developed by many organisms, from single cellular bacteria and fungi up to mammals including human, in order to adapt to 24-hour light/dark cycle. It was known for years that the circadian system controls many behavioral processes such as daily locomotor activity and sleep/wake cycle. What was emerging over last years is that the circadian clock is key regulator of metabolism, cardiovascular physiology, immune and stress response systems.

The main interest of the laboratory is circadian clock dependent mechanisms of diet and metabolism interaction. Dietary (calorie) restriction  is one of the most powerful interventions, which extend longevity in different organisms including mammals. We found that calorie restriction significantly affect circadian rhythms in gene expression and that functional circadian clock is necessary for lifespan extension by calorie restriction. We study circadian control of mTOR and insulin-like growth factor signaling pathways. These pathways play an important role in cell metabolism  and organism response to diet and stress.
Research Grants:

NIH 1 R01 AG039547 Role PI; 09.15.2011 ¿ 02.28.2022 Total cost: $3,000,000.00 ¿Circadian clock and dietary restriction¿.


NIH 1 R03 AG033881-01 Role PI; 03.01.2010 ¿ 02.28.2012; Total cost: $116,440.00;  ¿Circadian control of ROS homeostasis¿

CSU Scholarship Initiative. Role PI 07.01.2010 ¿ 06.30.2011 Total cost $5,000.00 ¿Role of BMAL1 protein in osteoblast differentiation¿  

FRD-Faculty Research and Development Award. Role: PI;  07.01.2008 ¿ 06.30.2011; Total cost $15,000.00; ¿BMALI and Oxidative Stress Response in Adult Stem Cells¿

State of Ohio Third Frontier/Ohio Board of Regents, Ohio Research Scholars Center of Research Excellence in Molecular Cardiovascular Innovation Role PI: 03.15.2009 ¿ 03.14.2010; Total cost $30,000.00; ¿Circadian Control of Antioxidant Defense, Platelet Reactivity and Thrombosis¿

AHA SDG 0835155N   Role: PI;   07.01.2008 ¿ 06.30.2013;    Total cost: $308,000.00; ¿Pharmacological modulation of circadian clock in cardiovascular system¿.