TY - JOUR
T1 - 2'-5'-oligoadenylate synthetase-like protein inhibits respiratory syncytial virus replication and is targeted by the viral nonstructural protein 1
AU - Dhar, Jayeeta
AU - Cuevas, Rolando A.
AU - Goswami, Ramansu
AU - Zhu, Jianzhong
AU - Sarkar, Saumendra N.
AU - Barik, Sailen
PY - 2015/1/1
Y1 - 2015/1/1
N2 - 2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome-dependent degradation of specific OASL isoforms. We conclude that OASL acts as a cellular antiviral protein and that RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
AB - 2'-5'-Oligoadenylate synthetase-like protein (OASL) is an interferon-inducible antiviral protein. Here we describe differential inhibitory activities of human OASL and the two mouse OASL homologs against respiratory syncytial virus (RSV) replication. Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome-dependent degradation of specific OASL isoforms. We conclude that OASL acts as a cellular antiviral protein and that RSV NS1 suppresses this function to evade cellular innate immunity and allow virus growth.
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U2 - 10.1128/JVI.01076-15
DO - 10.1128/JVI.01076-15
M3 - Article
C2 - 26178980
SN - 0022-538X
VL - 89
SP - 10115
EP - 10119
JO - Journal of Virology
JF - Journal of Virology
IS - 19
ER -