A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation

Robert  C Wirka; Shamone Gore; David  R Van Wagoner; Dan  E Arking; Steven  A Lubitz; Kathryn  L Lunetta; Emelia  J Benjamin; Alvaro Alonso; Pa T Ellinor; John Barnard; Mina  K Chung; Jonathan  D Smith; Shamone Gore Panter

A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation

Robert C Wirka
, Shamone Gore
, David R Van Wagoner
, Dan E Arking
, Steven A Lubitz
, Kathryn L Lunetta
, Emelia J Benjamin
, Alvaro Alonso
, Pa T Ellinor
, John Barnard
, Mina K Chung
, Jonathan D Smith
, Shamone Gore Panter

Biological, Geological, and Environmental Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A common single-nucleotide polymorphism (SNP) in the promoter of the Connexin-40 (Cx40) gene GJA5 was suggested to affect Cx40 promoter activity and the risk of atrial fibrillation (AF), but the role of other common Cx40 polymorphisms is unknown.

Original language	English
Number of pages	7
Journal	Circulation. Arrhythmia and electrophysiology
Volume	4
Issue number	1
State	Published - 2011

Cite this

Wirka, R. C., Gore, S., Van Wagoner, D. R., Arking, D. E., Lubitz, S. A., Lunetta, K. L., Benjamin, E. J., Alonso, A., Ellinor, P. T., Barnard, J., Chung, M. K., Smith, J. D., & Gore Panter, S. (2011). A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation. Circulation. Arrhythmia and electrophysiology, 4(1).

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title = "A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation",

abstract = "A common single-nucleotide polymorphism (SNP) in the promoter of the Connexin-40 (Cx40) gene GJA5 was suggested to affect Cx40 promoter activity and the risk of atrial fibrillation (AF), but the role of other common Cx40 polymorphisms is unknown.",

author = "Wirka, \{Robert C\} and Shamone Gore and \{Van Wagoner\}, \{David R\} and Arking, \{Dan E\} and Lubitz, \{Steven A\} and Lunetta, \{Kathryn L\} and Benjamin, \{Emelia J\} and Alvaro Alonso and Ellinor, \{Pa T\} and John Barnard and Chung, \{Mina K\} and Smith, \{Jonathan D\} and \{Gore Panter\}, Shamone",

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language = "English",

volume = "4",

journal = "Circulation. Arrhythmia and electrophysiology",

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T1 - A common connexin-40 gene promoter variant affects connexin-40 expression in human atria and is associated with atrial fibrillation

AU - Wirka, Robert C

AU - Gore, Shamone

AU - Van Wagoner, David R

AU - Arking, Dan E

AU - Lubitz, Steven A

AU - Lunetta, Kathryn L

AU - Benjamin, Emelia J

AU - Alonso, Alvaro

AU - Ellinor, Pa T

AU - Barnard, John

AU - Chung, Mina K

AU - Smith, Jonathan D

AU - Gore Panter, Shamone

PY - 2011

Y1 - 2011

N2 - A common single-nucleotide polymorphism (SNP) in the promoter of the Connexin-40 (Cx40) gene GJA5 was suggested to affect Cx40 promoter activity and the risk of atrial fibrillation (AF), but the role of other common Cx40 polymorphisms is unknown.

AB - A common single-nucleotide polymorphism (SNP) in the promoter of the Connexin-40 (Cx40) gene GJA5 was suggested to affect Cx40 promoter activity and the risk of atrial fibrillation (AF), but the role of other common Cx40 polymorphisms is unknown.

M3 - Article

VL - 4

JO - Circulation. Arrhythmia and electrophysiology

JF - Circulation. Arrhythmia and electrophysiology

IS - 1

ER -