Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

Yajia Zhang; Sethuramasundaram Pitchiaya; Yashar Niknafs; Jean Tien; Yasuyuki Hosono; Matthew Iyer; Sahr Yazdani; Shruthi Subramaniam; Sudhanshu Shukla; Xia Jiang; Lisha Wang; Tzu Liu; Michael Uhl; Alexander Gawronski; Yuanyuan Qiao; Lanbo Xiao; Saravana Dhanasekaran; Kristin Juckette; Lakshmi Kunju; Xuhong Cao; Utsav Patel; Mona Batish; Girish Shukla; Michelle Paulsen; Mats Ljungman; Hui Jiang; Rohit Mehra; Rolf Backofen; Cenk Sahinalp; Susan Freier; Andrew Watt; Shuling Guo; John Wei; Felix Feng; Rohit Malik; Arul Chinnaiyan; Marcin Cieślik

doi:10.1038/s41588-018-0120-1

Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

Yajia Zhang
, Sethuramasundaram Pitchiaya
, Yashar Niknafs
, Jean Tien
, Yasuyuki Hosono
, Matthew Iyer
, Sahr Yazdani
, Shruthi Subramaniam
, Sudhanshu Shukla
, Xia Jiang
, Lisha Wang
, Tzu Liu
, Michael Uhl
, Alexander Gawronski
, Yuanyuan Qiao
, Lanbo Xiao
, Saravana Dhanasekaran
, Kristin Juckette
, Lakshmi Kunju
, Xuhong Cao

Utsav Patel, Mona Batish, Girish Shukla, Michelle Paulsen, Mats Ljungman, Hui Jiang, Rohit Mehra, Rolf Backofen, Cenk Sahinalp, Susan Freier, Andrew Watt, Shuling Guo, John Wei, Felix Feng, Rohit Malik, Arul Chinnaiyan, Marcin Cieślik

Biological, Geological, and Environmental Sciences

Research output: Contribution to journal › Article

Abstract

The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.

Original language	English
Journal	Nature Genetics
Volume	50
Issue number	6
DOIs	https://doi.org/10.1038/s41588-018-0120-1
State	Published - 2018

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SDG 3 Good Health and Well-being

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10.1038/s41588-018-0120-1

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Zhang, Y., Pitchiaya, S., Niknafs, Y., Tien, J., Hosono, Y., Iyer, M., Yazdani, S., Subramaniam, S., Shukla, S., Jiang, X., Wang, L., Liu, T., Uhl, M., Gawronski, A., Qiao, Y., Xiao, L., Dhanasekaran, S., Juckette, K., Kunju, L., ... Cieślik, M. (2018). Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression. Nature Genetics, 50(6). https://doi.org/10.1038/s41588-018-0120-1

@article{b9d0d349cad247038a5b417583c73ece,

title = "Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression",

abstract = "The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.",

author = "Yajia Zhang and Sethuramasundaram Pitchiaya and Yashar Niknafs and Jean Tien and Yasuyuki Hosono and Matthew Iyer and Sahr Yazdani and Shruthi Subramaniam and Sudhanshu Shukla and Xia Jiang and Lisha Wang and Tzu Liu and Michael Uhl and Alexander Gawronski and Yuanyuan Qiao and Lanbo Xiao and Saravana Dhanasekaran and Kristin Juckette and Lakshmi Kunju and Xuhong Cao and Utsav Patel and Mona Batish and Girish Shukla and Michelle Paulsen and Mats Ljungman and Hui Jiang and Rohit Mehra and Rolf Backofen and Cenk Sahinalp and Susan Freier and Andrew Watt and Shuling Guo and John Wei and Felix Feng and Rohit Malik and Arul Chinnaiyan and Marcin Cie{\'s}lik",

year = "2018",

doi = "10.1038/s41588-018-0120-1",

language = "English",

volume = "50",

journal = "Nature Genetics",

number = "6",

}

Zhang, Y, Pitchiaya, S, Niknafs, Y, Tien, J, Hosono, Y, Iyer, M, Yazdani, S, Subramaniam, S, Shukla, S, Jiang, X, Wang, L, Liu, T, Uhl, M, Gawronski, A, Qiao, Y, Xiao, L, Dhanasekaran, S, Juckette, K, Kunju, L, Cao, X, Patel, U, Batish, M, Shukla, G, Paulsen, M, Ljungman, M, Jiang, H, Mehra, R, Backofen, R, Sahinalp, C, Freier, S, Watt, A, Guo, S, Wei, J, Feng, F, Malik, R, Chinnaiyan, A & Cieślik, M 2018, 'Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression', Nature Genetics, vol. 50, no. 6. https://doi.org/10.1038/s41588-018-0120-1

TY - JOUR

T1 - Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

AU - Zhang, Yajia

AU - Pitchiaya, Sethuramasundaram

AU - Niknafs, Yashar

AU - Tien, Jean

AU - Hosono, Yasuyuki

AU - Iyer, Matthew

AU - Yazdani, Sahr

AU - Subramaniam, Shruthi

AU - Shukla, Sudhanshu

AU - Jiang, Xia

AU - Wang, Lisha

AU - Liu, Tzu

AU - Uhl, Michael

AU - Gawronski, Alexander

AU - Qiao, Yuanyuan

AU - Xiao, Lanbo

AU - Dhanasekaran, Saravana

AU - Juckette, Kristin

AU - Kunju, Lakshmi

AU - Cao, Xuhong

AU - Patel, Utsav

AU - Batish, Mona

AU - Shukla, Girish

AU - Paulsen, Michelle

AU - Ljungman, Mats

AU - Jiang, Hui

AU - Mehra, Rohit

AU - Backofen, Rolf

AU - Sahinalp, Cenk

AU - Freier, Susan

AU - Watt, Andrew

AU - Guo, Shuling

AU - Wei, John

AU - Feng, Felix

AU - Malik, Rohit

AU - Chinnaiyan, Arul

AU - Cieślik, Marcin

PY - 2018

Y1 - 2018

N2 - The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.

AB - The androgen receptor (AR) plays a critical role in the development of the normal prostate as well as prostate cancer. Using an integrative transcriptomic analysis of prostate cancer cell lines and tissues, we identified ARLNC1 (AR-regulated long noncoding RNA 1) as an important long noncoding RNA that is strongly associated with AR signaling in prostate cancer progression. Not only was ARLNC1 induced by the AR protein, but ARLNC1 stabilized the AR transcript via RNA-RNA interaction. ARLNC1 knockdown suppressed AR expression, global AR signaling and prostate cancer growth in vitro and in vivo. Taken together, these data support a role for ARLNC1 in maintaining a positive feedback loop that potentiates AR signaling during prostate cancer progression and identify ARLNC1 as a novel therapeutic target.

UR - https://dx.doi.org/10.1038/s41588-018-0120-1

U2 - 10.1038/s41588-018-0120-1

DO - 10.1038/s41588-018-0120-1

M3 - Article

VL - 50

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Analysis of the androgen receptor-regulated lncRNA landscape identifies a role for ARLNC1 in prostate cancer progression

Abstract

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