TY - JOUR
T1 - Bisubstrate-type inhibitor of sialyltransferases
AU - Hinou, Hiroshi
AU - Sun, Xue
AU - Ito, Yukishige
PY - 2002/12/9
Y1 - 2002/12/9
N2 - A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory activities toward both 2,3-(N)- and 2,6-(N)-sialyltransferase. © 2002 Elsevier Science Ltd. All rights reserved.
AB - A convergent strategy for the construction of bisubstrate-type sialyltransferase inhibitor (1) was developed. It consists of consecutive coupling of three components (N-acetyllactosamine, sialic acid, and CMP), followed by oxidation and deprotection. As expected, compound 1 showed potent inhibitory activities toward both 2,3-(N)- and 2,6-(N)-sialyltransferase. © 2002 Elsevier Science Ltd. All rights reserved.
KW - Bisubstrate
KW - Inhibitor
KW - Sialyltransferase
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U2 - 10.1016/S0040-4039(02)02272-4
DO - 10.1016/S0040-4039(02)02272-4
M3 - Article
SN - 0040-4039
VL - 43
SP - 9147
EP - 9150
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 50
ER -