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Coinfection dynamics of two diseases in a single host population

  • Shanghai Normal University
  • University of California, San Francisco
  • University of California
  • University of Miami

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A susceptible-infectious-susceptible (SIS) epidemic model that describes the coinfection and cotransmission of two infectious diseases spreading through a single population is studied. The host population consists of two subclasses: susceptible and infectious, and the infectious individuals are further divided into three subgroups: those infected by the first agent/pathogen, the second agent/pathogen, and both. The basic reproduction numbers for all cases are derived which completely determine the global stability of the system if the presence of one agent/pathogen does not affect the transmission of the other. When the constraint on the transmissibility of the dually infected hosts is removed, we introduce the invasion reproduction number, compare it with two other types of reproduction number and show the uniform persistence of both diseases under certain conditions. Numerical simulations suggest that the system can display much richer dynamics such as backward bifurcation, bistability and Hopf bifurcation.
Original languageEnglish
Pages (from-to)171-188
Number of pages18
JournalJournal of Mathematical Analysis and Applications
Volume442
Issue number1
DOIs
StatePublished - Oct 1 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Backward bifurcation
  • Bistability
  • Coinfection
  • Hopf bifurcation
  • Invasion reproduction number
  • Uniform persistence

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