Abstract
Nanosecond, high intensity electric pulses create nanopores in the cell membrane. Pore formation energy is probed by taking account of the strain energy based on the continuum model. Maxwell stress acting on the cell membrane is included in the 3D model calculation as well as the effect of membrane curvature. In addition, comparison between cylindrical and toroidal pores were made to explore the difference of strain energy and force over the pores at a range of radii. Through the analyses the transmembrane potential were kept constant in order to obtain a transient response in that the electric pulse has a ultrashort duration and pore-evolving process is rapid as well. Our results demonstrate that under the same circumstances toroidal pores have higher strain energy than cylindrical pores due to the surface area and volume of the pore shape.
| Original language | English |
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| Title of host publication | Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference |
| Place of Publication | usa |
| Publisher | NLM (Medline) |
| Pages | 5721-5724 |
| Number of pages | 4 |
| Volume | 2018 |
| DOIs | |
| State | Published - Jul 1 2018 |
| Event | 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Duration: Jul 1 2018 → … |
Conference
| Conference | 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) |
|---|---|
| Period | 07/1/18 → … |
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