Components, Initiation, Elongation, Termination, and Regulation

Anton A Komar; William C. Merrick

doi:10.1016/B978-0-12-821618-7.00033-X

Components, Initiation, Elongation, Termination, and Regulation

Anton A Komar
, William C. Merrick

Case Western Reserve University

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

This article is intended to provide the reader with an overview of eukaryotic protein synthesis, from its component parts, to pathways for initiation, elongation and termination. The article addresses the consequences of global regulation as evidenced via eIF2 and 4E-BP phosphorylation, events that have differential effects on the pattern of protein synthesis. The process of protein synthesis is discussed based upon both cell free studies and studies in either yeast or tissue culture cells.

Original language	English
Title of host publication	Encyclopedia of Cell Biology: Volume 1-6, Second Edition
Place of Publication	nld
Publisher	Elsevier
Pages	676-688
Number of pages	13
Volume	1
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00033-X
State	Published - Jan 1 2022

Keywords

Aminoacylation
Cap-dependent translation
Elongation
Global regulation
Initiation
IRES-mediated translation
MRNA
Peptide bond formation
Protein phosphorylation
Protein synthesis
Termination and translation factors

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10.1016/B978-0-12-821618-7.00033-X

Cite this

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AU - Merrick, William C.

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AB - This article is intended to provide the reader with an overview of eukaryotic protein synthesis, from its component parts, to pathways for initiation, elongation and termination. The article addresses the consequences of global regulation as evidenced via eIF2 and 4E-BP phosphorylation, events that have differential effects on the pattern of protein synthesis. The process of protein synthesis is discussed based upon both cell free studies and studies in either yeast or tissue culture cells.

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KW - Cap-dependent translation

KW - Elongation

KW - Global regulation

KW - Initiation

KW - IRES-mediated translation

KW - MRNA

KW - Peptide bond formation

KW - Protein phosphorylation

KW - Protein synthesis

KW - Termination and translation factors

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EP - 688

BT - Encyclopedia of Cell Biology: Volume 1-6, Second Edition

PB - Elsevier

CY - nld

ER -

Components, Initiation, Elongation, Termination, and Regulation

Abstract

Keywords

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