Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76

Bo Zhong; Rati Lama; Kerri M. Smith; Yan Xu; Bin Su

doi:10.1016/j.bmcl.2011.07.025

Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76

Bo Zhong
, Rati Lama
, Kerri M. Smith
, Yan Xu
, Bin Su

Cleveland State University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon linker and biotin conjugated JCC76 probe was designed and synthesized. The anti-proliferation activity of the probe and its analogs was evaluated. © 2011 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	5324-5327
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2011.07.025
State	Published - Sep 15 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biotin
COX-2
JCC76
Nimesulide
Probe

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10.1016/j.bmcl.2011.07.025

Cite this

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title = "Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76",

abstract = "JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon linker and biotin conjugated JCC76 probe was designed and synthesized. The anti-proliferation activity of the probe and its analogs was evaluated. {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",

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AU - Zhong, Bo

AU - Lama, Rati

AU - Smith, Kerri M.

AU - Xu, Yan

AU - Su, Bin

PY - 2011/9/15

Y1 - 2011/9/15

N2 - JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon linker and biotin conjugated JCC76 probe was designed and synthesized. The anti-proliferation activity of the probe and its analogs was evaluated. © 2011 Elsevier Ltd. All rights reserved.

AB - JCC76 is a derivative of cyclooxygenase-2(COX-2) selective inhibitor nimesulide and exhibits potent anti-breast cancer activity. It selectively induces apoptosis of Her2 positive breast cancer cells. However, the specific molecular targets of JCC76 still remain unclear, which significantly withdraw the further drug development of JCC76. To identify the molecular targets of JCC76, a six carbon linker and biotin conjugated JCC76 probe was designed and synthesized. The anti-proliferation activity of the probe and its analogs was evaluated. © 2011 Elsevier Ltd. All rights reserved.

KW - Biotin

KW - COX-2

KW - JCC76

KW - Nimesulide

KW - Probe

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M3 - Article

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SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Design and synthesis of a biotinylated probe of COX-2 inhibitor nimesulide analog JCC76

Abstract

UN SDGs

Keywords

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