Effect of an oscillating magnetic field on the release properties of magnetic collagen gels

Vania De Paoli; Silvia H. De Paoli Lacerda; Leonard Spinu; Bruce Ingber; Zeev Rosenzweig; Nitsa Rosenzweig

doi:10.1021/la060280h

Effect of an oscillating magnetic field on the release properties of magnetic collagen gels

Vania De Paoli
, Silvia H. De Paoli Lacerda
, Leonard Spinu
, Bruce Ingber
, Zeev Rosenzweig
, Nitsa Rosenzweig

Chemistry

University of New Orleans
USDA-ARS Rangeland Resources & Systems Research Unit

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

The paper describes the effect of an oscillating magnetic field (OMF) on the morphology and release properties of collagen gels containing magnetic nanoparticles and microparticles and fluorescent drug analogues. Collagen gels were prepared through fibrillogenesis of collagen in the presence of iron oxide magnetic particles averaging 10 nm or 3 μm in diameter and rhodamine-labeled dextran (Dex-R) of molecular weights between 3000-70 000 g/mol. Dextran molecules effectively simulate protein-based drugs, since they have similar molecular weights and dimensions. The paper discusses the effect of an OMF on the release properties of the gels and proposes an empirical model to predict the release rate. It also demonstrates the self-repair capability of collagen gels following the structural damage caused by an OMF. © 2006 American Chemical Society.

Original language	English
Pages (from-to)	5894-5899
Number of pages	6
Journal	Langmuir
Volume	22
Issue number	13
DOIs	https://doi.org/10.1021/la060280h
State	Published - Jun 20 2006

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10.1021/la060280h

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abstract = "The paper describes the effect of an oscillating magnetic field (OMF) on the morphology and release properties of collagen gels containing magnetic nanoparticles and microparticles and fluorescent drug analogues. Collagen gels were prepared through fibrillogenesis of collagen in the presence of iron oxide magnetic particles averaging 10 nm or 3 μm in diameter and rhodamine-labeled dextran (Dex-R) of molecular weights between 3000-70 000 g/mol. Dextran molecules effectively simulate protein-based drugs, since they have similar molecular weights and dimensions. The paper discusses the effect of an OMF on the release properties of the gels and proposes an empirical model to predict the release rate. It also demonstrates the self-repair capability of collagen gels following the structural damage caused by an OMF. {\textcopyright} 2006 American Chemical Society.",

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AU - De Paoli, Vania

AU - De Paoli Lacerda, Silvia H.

AU - Spinu, Leonard

AU - Ingber, Bruce

AU - Rosenzweig, Zeev

AU - Rosenzweig, Nitsa

PY - 2006/6/20

Y1 - 2006/6/20

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AB - The paper describes the effect of an oscillating magnetic field (OMF) on the morphology and release properties of collagen gels containing magnetic nanoparticles and microparticles and fluorescent drug analogues. Collagen gels were prepared through fibrillogenesis of collagen in the presence of iron oxide magnetic particles averaging 10 nm or 3 μm in diameter and rhodamine-labeled dextran (Dex-R) of molecular weights between 3000-70 000 g/mol. Dextran molecules effectively simulate protein-based drugs, since they have similar molecular weights and dimensions. The paper discusses the effect of an OMF on the release properties of the gels and proposes an empirical model to predict the release rate. It also demonstrates the self-repair capability of collagen gels following the structural damage caused by an OMF. © 2006 American Chemical Society.

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Effect of an oscillating magnetic field on the release properties of magnetic collagen gels

Abstract

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