Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

Xinmin  S Li; Slayman Obeid; Roland Klingenberg; Baris Gencer; François Mach; Lorenz Räber; Stephan Windecker; Nicolas Rodondi; David Nanchen; Olivier Muller; Melroy  X Miranda; Christian  M Matter; Yuping Wu; Lin Li; Zeneng Wang; Ha S Alamri; Valentin Gogonea; Yoon- M Chung; W  H Tang; Stan L Hazen; Thomas  F Lüscher

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

Xinmin S Li
, Slayman Obeid
, Roland Klingenberg
, Baris Gencer
, François Mach
, Lorenz Räber
, Stephan Windecker
, Nicolas Rodondi
, David Nanchen
, Olivier Muller
, Melroy X Miranda
, Christian M Matter
, Yuping Wu
, Lin Li
, Zeneng Wang
, Ha S Alamri
, Valentin Gogonea
, Yoon- M Chung
, W H Tang
, Stan L Hazen

Thomas F Lüscher

Research output: Contribution to journal › Article

Abstract

Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary and secondary prevention subjects. However, the prognostic value of TMAO in the setting of acute coronary syndromes (ACS) remains unknown.

Original language	English
Number of pages	11
Journal	European heart journal
Volume	38
Issue number	11
State	Published - 2017

Cite this

Li, X. S., Obeid, S., Klingenberg, R., Gencer, B., Mach, F., Räber, L., Windecker, S., Rodondi, N., Nanchen, D., Muller, O., Miranda, M. X., Matter, C. M., Wu, Y., Li, L., Wang, Z., Alamri, H. S., Gogonea, V., Chung, Y. M., Tang, W. H., ... Lüscher, T. F. (2017). Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors. European heart journal, 38(11).

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title = "Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors",

abstract = "Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary and secondary prevention subjects. However, the prognostic value of TMAO in the setting of acute coronary syndromes (ACS) remains unknown.",

author = "Li, \{Xinmin S\} and Slayman Obeid and Roland Klingenberg and Baris Gencer and Fran{\c c}ois Mach and Lorenz R{\"a}ber and Stephan Windecker and Nicolas Rodondi and David Nanchen and Olivier Muller and Miranda, \{Melroy X\} and Matter, \{Christian M\} and Yuping Wu and Lin Li and Zeneng Wang and Alamri, \{Ha S\} and Valentin Gogonea and Chung, \{Yoon- M\} and Tang, \{W H\} and Hazen, \{Stan L\} and L{\"u}scher, \{Thomas F\}",

year = "2017",

language = "English",

volume = "38",

journal = "European heart journal",

number = "11",

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Li, XS, Obeid, S, Klingenberg, R, Gencer, B, Mach, F, Räber, L, Windecker, S, Rodondi, N, Nanchen, D, Muller, O, Miranda, MX, Matter, CM, Wu, Y, Li, L, Wang, Z, Alamri, HS, Gogonea, V, Chung, YM, Tang, WH, Hazen, SL & Lüscher, TF 2017, 'Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors', European heart journal, vol. 38, no. 11.

TY - JOUR

T1 - Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors

AU - Li, Xinmin S

AU - Obeid, Slayman

AU - Klingenberg, Roland

AU - Gencer, Baris

AU - Mach, François

AU - Räber, Lorenz

AU - Windecker, Stephan

AU - Rodondi, Nicolas

AU - Nanchen, David

AU - Muller, Olivier

AU - Miranda, Melroy X

AU - Matter, Christian M

AU - Wu, Yuping

AU - Li, Lin

AU - Wang, Zeneng

AU - Alamri, Ha S

AU - Gogonea, Valentin

AU - Chung, Yoon- M

AU - Tang, W H

AU - Hazen, Stan L

AU - Lüscher, Thomas F

PY - 2017

Y1 - 2017

N2 - Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary and secondary prevention subjects. However, the prognostic value of TMAO in the setting of acute coronary syndromes (ACS) remains unknown.

AB - Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism of dietary trimethylamine (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary and secondary prevention subjects. However, the prognostic value of TMAO in the setting of acute coronary syndromes (ACS) remains unknown.

M3 - Article

VL - 38

JO - European heart journal

JF - European heart journal

IS - 11

ER -