Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

W H Wilson Tang; Zeneng Wang; David J Kennedy; Yuping Wu; Jennifer A Buffa; Brendan Agatisa-Boyle; Xinmin S Li; Bruce S Levison; Stanley L Hazen

Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

W H Wilson Tang
, Zeneng Wang
, David J Kennedy
, Yuping Wu
, Jennifer A Buffa
, Brendan Agatisa-Boyle
, Xinmin S Li
, Bruce S Levison
, Stanley L Hazen

Mathematics and Statistics

Research output: Contribution to journal › Article

Abstract

Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

Original language	English
Number of pages	392
Journal	Circulation research
Volume	116
Issue number	3
State	Published - 2015

Cite this

@article{a135a0689841463aa440cd5e186d7599,

title = "Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease",

abstract = "Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.",

author = "Tang, \{W H Wilson\} and Zeneng Wang and Kennedy, \{David J\} and Yuping Wu and Buffa, \{Jennifer A\} and Brendan Agatisa-Boyle and Li, \{Xinmin S\} and Levison, \{Bruce S\} and Hazen, \{Stanley L\}",

year = "2015",

language = "English",

volume = "116",

journal = "Circulation research",

number = "3",

}

TY - JOUR

T1 - Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

AU - Tang, W H Wilson

AU - Wang, Zeneng

AU - Kennedy, David J

AU - Wu, Yuping

AU - Buffa, Jennifer A

AU - Agatisa-Boyle, Brendan

AU - Li, Xinmin S

AU - Levison, Bruce S

AU - Hazen, Stanley L

PY - 2015

Y1 - 2015

N2 - Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

AB - Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and l-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis.

M3 - Article

VL - 116

JO - Circulation research

JF - Circulation research

IS - 3

ER -