Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses

Hao Qiu; Xianping Wang; Anthony Choi; Fei Xie; Wenbing Zhao

doi:10.1109/EMBC.2018.8513372

Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses

Hao Qiu
, Xianping Wang
, Anthony Choi
, Fei Xie
, Wenbing Zhao

Electrical and Computer Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Ultrashort, high-intensity electric pulses open nanopores in biological cell membranes. Ion transport in nanopore is analyzed using a numerical method that couples the Nernst-Planck equations for ionic concentrations, the Poisson equation for the electric potential, and Navier-Stokes equations for the fluid flow. Roles of the applied bias, pore size, as well as the surface charge lining the membrane are comprehensively examined through I-V characteristics, conductance variations of the pore. Our results show that the surface charge distribution has an impact on the ionic conduction due to mutual electrostatic force interference. In addition, a larger pore would conduct a larger ionic current thus being more conductive on the condition of the same bias applied, which would suggest a bias-dependent expansion of pores.

Original language	English
Title of host publication	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Place of Publication	usa
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1-4
Number of pages	4
Volume	2018-July
ISBN (Electronic)	9781538636466
DOIs	https://doi.org/10.1109/EMBC.2018.8513372
State	Published - Oct 26 2018
Event	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States Duration: Jul 18 2018 → Jul 21 2018

Conference

Conference	40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
Country/Territory	United States
City	Honolulu
Period	07/18/18 → 07/21/18

Keywords

PNP-NS
ions transport
nanopore

Access to Document

10.1109/EMBC.2018.8513372

Cite this

Qiu, H., Wang, X., Choi, A., Xie, F., & Zhao, W. (2018). Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2018-July, pp. 1-4). Article 8513372 Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8513372

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abstract = "Ultrashort, high-intensity electric pulses open nanopores in biological cell membranes. Ion transport in nanopore is analyzed using a numerical method that couples the Nernst-Planck equations for ionic concentrations, the Poisson equation for the electric potential, and Navier-Stokes equations for the fluid flow. Roles of the applied bias, pore size, as well as the surface charge lining the membrane are comprehensively examined through I-V characteristics, conductance variations of the pore. Our results show that the surface charge distribution has an impact on the ionic conduction due to mutual electrostatic force interference. In addition, a larger pore would conduct a larger ionic current thus being more conductive on the condition of the same bias applied, which would suggest a bias-dependent expansion of pores.",

keywords = "PNP-NS, ions transport, nanopore",

author = "Hao Qiu and Xianping Wang and Anthony Choi and Fei Xie and Wenbing Zhao",

year = "2018",

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doi = "10.1109/EMBC.2018.8513372",

language = "English",

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booktitle = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Qiu, H, Wang, X, Choi, A, Xie, F & Zhao, W 2018, Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2018-July, 8513372, Institute of Electrical and Electronics Engineers Inc., usa, pp. 1-4, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 07/18/18. https://doi.org/10.1109/EMBC.2018.8513372

Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses. / Qiu, Hao; Wang, Xianping; Choi, Anthony et al.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2018-July usa: Institute of Electrical and Electronics Engineers Inc., 2018. p. 1-4 8513372.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses

AU - Qiu, Hao

AU - Wang, Xianping

AU - Choi, Anthony

AU - Xie, Fei

AU - Zhao, Wenbing

PY - 2018/10/26

Y1 - 2018/10/26

N2 - Ultrashort, high-intensity electric pulses open nanopores in biological cell membranes. Ion transport in nanopore is analyzed using a numerical method that couples the Nernst-Planck equations for ionic concentrations, the Poisson equation for the electric potential, and Navier-Stokes equations for the fluid flow. Roles of the applied bias, pore size, as well as the surface charge lining the membrane are comprehensively examined through I-V characteristics, conductance variations of the pore. Our results show that the surface charge distribution has an impact on the ionic conduction due to mutual electrostatic force interference. In addition, a larger pore would conduct a larger ionic current thus being more conductive on the condition of the same bias applied, which would suggest a bias-dependent expansion of pores.

AB - Ultrashort, high-intensity electric pulses open nanopores in biological cell membranes. Ion transport in nanopore is analyzed using a numerical method that couples the Nernst-Planck equations for ionic concentrations, the Poisson equation for the electric potential, and Navier-Stokes equations for the fluid flow. Roles of the applied bias, pore size, as well as the surface charge lining the membrane are comprehensively examined through I-V characteristics, conductance variations of the pore. Our results show that the surface charge distribution has an impact on the ionic conduction due to mutual electrostatic force interference. In addition, a larger pore would conduct a larger ionic current thus being more conductive on the condition of the same bias applied, which would suggest a bias-dependent expansion of pores.

KW - PNP-NS

KW - ions transport

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Qiu H, Wang X, Choi A, Xie F, Zhao W. Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2018-July. usa: Institute of Electrical and Electronics Engineers Inc. 2018. p. 1-4. 8513372 doi: 10.1109/EMBC.2018.8513372

Ionic Conduction in Biological Nanopores Created by Ultrashort9 High-Intensity Pulses

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Keywords

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