TY - JOUR
T1 - Optimization of Gold Nanoparticle Synthesis in Continuous-Flow Micromixers Using Response Surface Methodology
AU - Sarsfield, Marissa
AU - Roberts, Alexa
AU - Streletzky, Kiril A
AU - Fodor, Petru S
AU - Kothapalli, Chandrasekhar Rama
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Gold nanoparticles (AuNPs) were synthesized in microfluidic mixers by means of response surface methodology (RSM). A reverse-staggered herringbone micromixer was employed and reaction temperature, concentration ratio of reactants, Reynolds number, and pH of chloroauric acid were varied, with desired responses being particle size and peak intensity from UV spectroscopy. RSM was performed by simultaneously optimizing variable ranges to identify the best fit of polynomial equations to experimental data. Results revealed the individual and synergistic roles of each reaction variable on particle size and UV peak intensity, leading to identification of the largest design space. The effect of reaction variables on AuNP synthesis and particle size was confirmed in serpentine mixers.
AB - Gold nanoparticles (AuNPs) were synthesized in microfluidic mixers by means of response surface methodology (RSM). A reverse-staggered herringbone micromixer was employed and reaction temperature, concentration ratio of reactants, Reynolds number, and pH of chloroauric acid were varied, with desired responses being particle size and peak intensity from UV spectroscopy. RSM was performed by simultaneously optimizing variable ranges to identify the best fit of polynomial equations to experimental data. Results revealed the individual and synergistic roles of each reaction variable on particle size and UV peak intensity, leading to identification of the largest design space. The effect of reaction variables on AuNP synthesis and particle size was confirmed in serpentine mixers.
KW - Dean flow mixers
KW - Design of experiments
KW - Gold nanoparticles
KW - Response surface methodology
KW - Reverse-staggered herringbone design
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U2 - 10.1002/ceat.202000314
DO - 10.1002/ceat.202000314
M3 - Article
SN - 0930-7516
VL - 44
SP - 622
EP - 630
JO - Chemical Engineering and Technology
JF - Chemical Engineering and Technology
IS - 4
ER -