Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis

Annette Bellar; Nicole Welch; Jaividhya Dasarathy; Amy Attaway; Ryan Musich; Avinash Kumar; Jinendiran Sekar; Saurabh Mishra; Yana Sandlers; David Streem; Laura  E Nagy; Srinivasan Dasarathy

Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis

Annette Bellar
, Nicole Welch
, Jaividhya Dasarathy
, Amy Attaway
, Ryan Musich
, Avinash Kumar
, Jinendiran Sekar
, Saurabh Mishra
, Yana Sandlers
, David Streem
, Laura E Nagy
, Srinivasan Dasarathy

Chemistry

Research output: Contribution to journal › Article

Abstract

Patients with acute alcohol-associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformatics-experimental validation of mitochondrial responses were performed in peripheral blood mononuclear cells (PBMC) from patients with AH, healthy controls (HC), and heavy drinkers without evidence of liver disease (HD).

Original language	English
Journal	Clinical and translational medicine
Volume	13
Issue number	5
State	Published - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

@article{f08fcfff49c94c1db13185b5c94748dc,

title = "Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis",

abstract = "Patients with acute alcohol-associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformatics-experimental validation of mitochondrial responses were performed in peripheral blood mononuclear cells (PBMC) from patients with AH, healthy controls (HC), and heavy drinkers without evidence of liver disease (HD).",

author = "Annette Bellar and Nicole Welch and Jaividhya Dasarathy and Amy Attaway and Ryan Musich and Avinash Kumar and Jinendiran Sekar and Saurabh Mishra and Yana Sandlers and David Streem and Nagy, \{Laura E\} and Srinivasan Dasarathy",

year = "2023",

language = "English",

volume = "13",

journal = "Clinical and translational medicine",

number = "5",

}

TY - JOUR

T1 - Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis

AU - Bellar, Annette

AU - Welch, Nicole

AU - Dasarathy, Jaividhya

AU - Attaway, Amy

AU - Musich, Ryan

AU - Kumar, Avinash

AU - Sekar, Jinendiran

AU - Mishra, Saurabh

AU - Sandlers, Yana

AU - Streem, David

AU - Nagy, Laura E

AU - Dasarathy, Srinivasan

PY - 2023

Y1 - 2023

N2 - Patients with acute alcohol-associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformatics-experimental validation of mitochondrial responses were performed in peripheral blood mononuclear cells (PBMC) from patients with AH, healthy controls (HC), and heavy drinkers without evidence of liver disease (HD).

AB - Patients with acute alcohol-associated hepatitis (AH) have immune dysfunction. Mitochondrial function is critical for immune cell responses and regulates senescence. Clinical translational studies using complementary bioinformatics-experimental validation of mitochondrial responses were performed in peripheral blood mononuclear cells (PBMC) from patients with AH, healthy controls (HC), and heavy drinkers without evidence of liver disease (HD).

M3 - Article

VL - 13

JO - Clinical and translational medicine

JF - Clinical and translational medicine

IS - 5

ER -