Plasmodium yoelii: Novel rhoptry proteins identified within the body of merozoite rhoptries in rodent Plasmodium malaria

Tobili Sam-Yellowe; Tashara L. Banks; Hisashi Fujioka; Judith A. Drazba; Satya P. Yadav

doi:10.1016/j.exppara.2008.05.001

Plasmodium yoelii: Novel rhoptry proteins identified within the body of merozoite rhoptries in rodent Plasmodium malaria

Tobili Sam-Yellowe
, Tashara L. Banks
, Hisashi Fujioka
, Judith A. Drazba
, Satya P. Yadav

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis. The antisera were used in immunofluorescence and immunoelectron microscopy of schizont-infected erythrocytes. Twenty-seven novel rhoptry proteins representing proteases, metabolic enzymes, secreted proteins and hypothetical proteins, were identified in the body of the rhoptries by immunoelectron microscopy. The merozoite rhoptries contain a heterogeneous mixture of proteins that may initiate host cell invasion and establish intracellular parasite development. © 2008 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Experimental Parasitology
Volume	120
Issue number	1
DOIs	https://doi.org/10.1016/j.exppara.2008.05.001
State	Published - Sep 1 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apical complex organelles
Immunoelectron microscopy
Merozoites
Plasmodium berghei
Plasmodium chabaudi
Plasmodium falciparum
Plasmodium yoelii
Proteome
Rhoptries

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10.1016/j.exppara.2008.05.001

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title = "Plasmodium yoelii: Novel rhoptry proteins identified within the body of merozoite rhoptries in rodent Plasmodium malaria",

abstract = "The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis. The antisera were used in immunofluorescence and immunoelectron microscopy of schizont-infected erythrocytes. Twenty-seven novel rhoptry proteins representing proteases, metabolic enzymes, secreted proteins and hypothetical proteins, were identified in the body of the rhoptries by immunoelectron microscopy. The merozoite rhoptries contain a heterogeneous mixture of proteins that may initiate host cell invasion and establish intracellular parasite development. {\textcopyright} 2008 Elsevier Inc. All rights reserved.",

keywords = "Apical complex organelles, Immunoelectron microscopy, Merozoites, Plasmodium berghei, Plasmodium chabaudi, Plasmodium falciparum, Plasmodium yoelii, Proteome, Rhoptries",

author = "Tobili Sam-Yellowe and Banks, \{Tashara L.\} and Hisashi Fujioka and Drazba, \{Judith A.\} and Yadav, \{Satya P.\}",

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doi = "10.1016/j.exppara.2008.05.001",

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AU - Sam-Yellowe, Tobili

AU - Banks, Tashara L.

AU - Fujioka, Hisashi

AU - Drazba, Judith A.

AU - Yadav, Satya P.

PY - 2008/9/1

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AB - The biogenesis, organization and function of the rhoptries are not well understood. Antisera were prepared to synthetic peptides prepared as multiple antigenic peptides (MAPs) obtained from a Plasmodium yoelii merozoite rhoptry proteome analysis. The antisera were used in immunofluorescence and immunoelectron microscopy of schizont-infected erythrocytes. Twenty-seven novel rhoptry proteins representing proteases, metabolic enzymes, secreted proteins and hypothetical proteins, were identified in the body of the rhoptries by immunoelectron microscopy. The merozoite rhoptries contain a heterogeneous mixture of proteins that may initiate host cell invasion and establish intracellular parasite development. © 2008 Elsevier Inc. All rights reserved.

KW - Apical complex organelles

KW - Immunoelectron microscopy

KW - Merozoites

KW - Plasmodium berghei

KW - Plasmodium chabaudi

KW - Plasmodium falciparum

KW - Plasmodium yoelii

KW - Proteome

KW - Rhoptries

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ER -

Plasmodium yoelii: Novel rhoptry proteins identified within the body of merozoite rhoptries in rodent Plasmodium malaria

Abstract

UN SDGs

Keywords

Access to Document

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