Abstract
Several compounds were isolated from the Fischer's methylation reaction mixture of 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) with hydrochloric acid or methanesulfonic acid in methanol. The major product was methyl (methyl 3-deoxy-β-D-glycero-D-galacto-2-nonulopyranosid)onate (2), which we have already reported. New furan derivatives and a 4,8-anhydro product were also isolated. The structures of these compounds were elucidated by nuclear magnetic resonance spectroscopy and X-ray cristallographic analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 208-211 |
| Number of pages | 4 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1996 |
Keywords
- 4,8-anhydro product
- Crystalline KDN
- Fischer's glycosylation
- Furan derivative
- Sialic acid
- β-elimination
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