Simulation of electroporation in cell using bipolar AC pulse

Hao Qiu; Xianping Wang; Wenbing Zhao

doi:10.1109/IMBIOC.2018.8428837

Simulation of electroporation in cell using bipolar AC pulse

Hao Qiu
, Xianping Wang
, Wenbing Zhao

Electrical and Computer Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Electroporation in a single cell was numerically simulated using bipolar AC electric pulses. A cell of 20 μm in diameter was placed in the center of a microchannel with 100 μm width and height and AC sine pulse with 2kV/cm electric field and 100 kHz in frequency were applied on the electrodes at the top and bottom of the microchannel. Our obtained simulation results show that most nanopores are created around the poles of cell. The transmembrane potential would be influenced by the shape of the external applied voltage. Additionally, the numerical simulation also demonstrate the conductivity of porated area increase tremendously compared to that of the non-porated area.

Original language	English
Title of host publication	IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference
Place of Publication	usa
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	187-189
Number of pages	3
ISBN (Print)	9781538659182
DOIs	https://doi.org/10.1109/IMBIOC.2018.8428837
State	Published - Aug 7 2018
Event	2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018 - Philadelphia, United States Duration: Jun 14 2018 → Jun 15 2018

Conference

Conference	2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018
Country/Territory	United States
City	Philadelphia
Period	06/14/18 → 06/15/18

Keywords

AC electric pulse
Electroporation
Transmembrane potential

Access to Document

10.1109/IMBIOC.2018.8428837

Cite this

@inproceedings{b1551dfe357e4757a2109598f06093a5,

title = "Simulation of electroporation in cell using bipolar AC pulse",

abstract = "Electroporation in a single cell was numerically simulated using bipolar AC electric pulses. A cell of 20 μm in diameter was placed in the center of a microchannel with 100 μm width and height and AC sine pulse with 2kV/cm electric field and 100 kHz in frequency were applied on the electrodes at the top and bottom of the microchannel. Our obtained simulation results show that most nanopores are created around the poles of cell. The transmembrane potential would be influenced by the shape of the external applied voltage. Additionally, the numerical simulation also demonstrate the conductivity of porated area increase tremendously compared to that of the non-porated area.",

keywords = "AC electric pulse, Electroporation, Transmembrane potential",

author = "Hao Qiu and Xianping Wang and Wenbing Zhao",

year = "2018",

month = aug,

day = "7",

doi = "10.1109/IMBIOC.2018.8428837",

language = "English",

isbn = "9781538659182",

pages = "187--189",

booktitle = "IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018 ; Conference date: 14-06-2018 Through 15-06-2018",

}

Qiu, H, Wang, X & Zhao, W 2018, Simulation of electroporation in cell using bipolar AC pulse. in IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference., 8428837, Institute of Electrical and Electronics Engineers Inc., usa, pp. 187-189, 2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018, Philadelphia, United States, 06/14/18. https://doi.org/10.1109/IMBIOC.2018.8428837

Simulation of electroporation in cell using bipolar AC pulse. / Qiu, Hao; Wang, Xianping; Zhao, Wenbing.
IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference. usa: Institute of Electrical and Electronics Engineers Inc., 2018. p. 187-189 8428837.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Simulation of electroporation in cell using bipolar AC pulse

AU - Qiu, Hao

AU - Wang, Xianping

AU - Zhao, Wenbing

PY - 2018/8/7

Y1 - 2018/8/7

N2 - Electroporation in a single cell was numerically simulated using bipolar AC electric pulses. A cell of 20 μm in diameter was placed in the center of a microchannel with 100 μm width and height and AC sine pulse with 2kV/cm electric field and 100 kHz in frequency were applied on the electrodes at the top and bottom of the microchannel. Our obtained simulation results show that most nanopores are created around the poles of cell. The transmembrane potential would be influenced by the shape of the external applied voltage. Additionally, the numerical simulation also demonstrate the conductivity of porated area increase tremendously compared to that of the non-porated area.

AB - Electroporation in a single cell was numerically simulated using bipolar AC electric pulses. A cell of 20 μm in diameter was placed in the center of a microchannel with 100 μm width and height and AC sine pulse with 2kV/cm electric field and 100 kHz in frequency were applied on the electrodes at the top and bottom of the microchannel. Our obtained simulation results show that most nanopores are created around the poles of cell. The transmembrane potential would be influenced by the shape of the external applied voltage. Additionally, the numerical simulation also demonstrate the conductivity of porated area increase tremendously compared to that of the non-porated area.

KW - AC electric pulse

KW - Electroporation

KW - Transmembrane potential

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U2 - 10.1109/IMBIOC.2018.8428837

DO - 10.1109/IMBIOC.2018.8428837

M3 - Conference contribution

SN - 9781538659182

SP - 187

EP - 189

BT - IMBioc 2018 - 2018 IEEE/MTT-S International Microwave Biomedical Conference

PB - Institute of Electrical and Electronics Engineers Inc.

CY - usa

T2 - 2018 IEEE/MTT-S International Microwave Biomedical Conference, IMBioc 2018

Y2 - 14 June 2018 through 15 June 2018

ER -

Simulation of electroporation in cell using bipolar AC pulse

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Keywords

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