TY - JOUR
T1 - Sphingomyelin depletion impairs anionic phospholipid inward translocation and induces cholesterol efflux
AU - Gulshan, K.
AU - Brubaker, Gregory
AU - Wang, Shuhui
AU - Hazen, Stanley L.
AU - Smith, Jonathan D.
PY - 2013/12/27
Y1 - 2013/12/27
N2 - Background: Phosphatidylserine floppase activity of ABCA1 is required for optimal cholesterol efflux, as demonstrated via a floppase-impaired ABCA1 mutation. Results: Sphingomyelin depletion compensates for floppase-impaired ABCA1 and increases cell surface phosphatidylserine. Conclusion: Sphingomyelin depletion inhibits flip of anionic phospholipids and thus promotes cholesterol efflux. Significance: Flippase inhibition may serve as a novel drug target to increase cholesterol efflux. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
AB - Background: Phosphatidylserine floppase activity of ABCA1 is required for optimal cholesterol efflux, as demonstrated via a floppase-impaired ABCA1 mutation. Results: Sphingomyelin depletion compensates for floppase-impaired ABCA1 and increases cell surface phosphatidylserine. Conclusion: Sphingomyelin depletion inhibits flip of anionic phospholipids and thus promotes cholesterol efflux. Significance: Flippase inhibition may serve as a novel drug target to increase cholesterol efflux. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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U2 - 10.1074/jbc.M113.512244
DO - 10.1074/jbc.M113.512244
M3 - Article
SN - 0021-9258
VL - 288
SP - 37166
EP - 37179
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 52
ER -