TY - JOUR
T1 - Straightforward Synthesis of N-Glycan Polymers from Free Glycans via Cyanoxyl Free Radical-Mediated Polymerization
AU - Tang, Jinshan
AU - Ozhegov, Evgeny
AU - Liu, Yang
AU - Wang, Dan
AU - Yao, Xinsheng
AU - Sun, Xue-Long
PY - 2017/2/21
Y1 - 2017/2/21
N2 - We report a straightforward synthesis of N-glycan polymers from free glycans via glycosylamine intermediates followed by acrylation and polymerization via cyanoxyl-mediated free radical polymerization (CMFRP) in one-pot fashion. No protection and deprotection were used in either glycomonomer or glycopolymer synthesis. A typical synthetic procedure for N-glycan polymers from free monosaccharide and disaccharide, Glc, Gal, Man, GlcNAc, and Lac, was demonstrated. In addition, enzymatic sialylation of the Lac-containing N-glycan polymers and their anti-influenza virus hemagglutination activities were investigated.
AB - We report a straightforward synthesis of N-glycan polymers from free glycans via glycosylamine intermediates followed by acrylation and polymerization via cyanoxyl-mediated free radical polymerization (CMFRP) in one-pot fashion. No protection and deprotection were used in either glycomonomer or glycopolymer synthesis. A typical synthetic procedure for N-glycan polymers from free monosaccharide and disaccharide, Glc, Gal, Man, GlcNAc, and Lac, was demonstrated. In addition, enzymatic sialylation of the Lac-containing N-glycan polymers and their anti-influenza virus hemagglutination activities were investigated.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017546817&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85017546817&origin=inward
U2 - 10.1021/acsmacrolett.6b00928
DO - 10.1021/acsmacrolett.6b00928
M3 - Article
C2 - 35632901
SN - 2161-1653
VL - 6
SP - 107
EP - 111
JO - ACS Macro Letters
JF - ACS Macro Letters
IS - 2
ER -