Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin

Cherie L. Stabler; Xue Sun; Wanxing Cui; John T. Wilson; Carolyn A. Haller; Elliot L. Chaikof

doi:10.1021/bc7002814

Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin

Cherie L. Stabler
, Xue Sun
, Wanxing Cui
, John T. Wilson
, Carolyn A. Haller
, Elliot L. Chaikof

University of Miami
Emory University

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses. © 2007 American Chemical Society.

Original language	English
Pages (from-to)	1713-1715
Number of pages	3
Journal	Bioconjugate Chemistry
Volume	18
Issue number	6
DOIs	https://doi.org/10.1021/bc7002814
State	Published - Jan 1 2007

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10.1021/bc7002814

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abstract = "Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses. {\textcopyright} 2007 American Chemical Society.",

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AU - Stabler, Cherie L.

AU - Sun, Xue

AU - Cui, Wanxing

AU - Wilson, John T.

AU - Haller, Carolyn A.

AU - Chaikof, Elliot L.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses. © 2007 American Chemical Society.

AB - Chemoselective conjugation of an azido-functionalized thrombomodulin to pancreatic islets was achieved by Staudinger ligation to a surface-bound bifunctional poly(ethylene glycol) linker. The presence of the tethered thrombomodulin resulted in a significant increase in the production of activated protein C with a reduction in islet-mediated thrombogenicity. This report highlights the potential of tissue-targeted chemistry to reduce donor cell mediated procoagulant and proinflammatory responses. © 2007 American Chemical Society.

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JO - Bioconjugate Chemistry

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Surface re-engineering of pancreatic islets with recombinant azido-thrombomodulin

Abstract

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