Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine

L. Sun; H. Liu; J. M. Orban; L. Sun; Elliot L. Chaikof

doi:10.1021/bc015502w

Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine

L. Sun
, H. Liu
, J. M. Orban
, L. Sun
, Elliot L. Chaikof

Chemistry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(ε-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.

Original language	English
Pages (from-to)	673-677
Number of pages	5
Journal	Bioconjugate Chemistry
Volume	12
Issue number	5
DOIs	https://doi.org/10.1021/bc015502w
State	Published - Jan 1 2001

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abstract = "We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(ε-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.",

author = "L. Sun and H. Liu and Orban, \{J. M.\} and L. Sun and Chaikof, \{Elliot L.\}",

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AU - Sun, L.

AU - Liu, H.

AU - Orban, J. M.

AU - Sun, L.

AU - Chaikof, Elliot L.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(ε-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.

AB - We report the design and synthesis of bifunctional phospholipid conjugates, which contain a polymerizable acrylate group and a terminal linker, such as biotin or N-(ε-maleimidocaproyl (EMC), to facilitate bioconjugation reactions. The lipid conjugate can be used to generate a multifunctional substrate-supported phospholipid film that is further stabilized via in-situ photocopolymerization.

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Synthesis and terminal functionalization of a polymerizable phosphatidylethanolamine

Abstract

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