Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity

Brian C. Lin; Katarzyna I. Jankowska; Upendra K. Katneni; Randilu Amarasinghe; Nigam Padhiar; Nobuko Hamasaki-Katagiri; Wells W. Wu; Haojie Zhu; Hideki Taguchi; Arnab Ghosh; David D. Holcomb; Je-Nie Phue; Sarah E. Fumagalli; Darón I. Freedberg; Ofer Kimchi; Rong-Fong Shen; Anton  A Komar; Zuben E. Sauna; Chava Kimchi-Sarfaty

doi:10.1093/procel/pwaf028

Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity

Brian C. Lin
, Katarzyna I. Jankowska
, Upendra K. Katneni
, Randilu Amarasinghe
, Nigam Padhiar
, Nobuko Hamasaki-Katagiri
, Wells W. Wu
, Haojie Zhu
, Hideki Taguchi
, Arnab Ghosh
, David D. Holcomb
, Je-Nie Phue
, Sarah E. Fumagalli
, Darón I. Freedberg
, Ofer Kimchi
, Rong-Fong Shen
, Anton A Komar
, Zuben E. Sauna
, Chava Kimchi-Sarfaty

Division of Plasma Protein Therapeutics Food and Drug Administration
Tokyo Institute of Technology
Cleveland State University
Princeton University

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	905-910
Number of pages	6
Journal	Protein and Cell
Volume	16
Issue number	10
DOIs	https://doi.org/10.1093/procel/pwaf028
State	Published - Oct 1 2025

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10.1093/procel/pwaf028

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Lin, B. C., Jankowska, K. I., Katneni, U. K., Amarasinghe, R., Padhiar, N., Hamasaki-Katagiri, N., Wu, W. W., Zhu, H., Taguchi, H., Ghosh, A., Holcomb, D. D., Phue, J.-N., Fumagalli, S. E., Freedberg, D. I., Kimchi, O., Shen, R.-F., Komar, A. A., Sauna, Z. E., & Kimchi-Sarfaty, C. (2025). Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity. Protein and Cell, 16(10), 905-910. https://doi.org/10.1093/procel/pwaf028

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title = "Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity",

author = "Lin, \{Brian C.\} and Jankowska, \{Katarzyna I.\} and Katneni, \{Upendra K.\} and Randilu Amarasinghe and Nigam Padhiar and Nobuko Hamasaki-Katagiri and Wu, \{Wells W.\} and Haojie Zhu and Hideki Taguchi and Arnab Ghosh and Holcomb, \{David D.\} and Je-Nie Phue and Fumagalli, \{Sarah E.\} and Freedberg, \{Dar{\'o}n I.\} and Ofer Kimchi and Rong-Fong Shen and Komar, \{Anton A\} and Sauna, \{Zuben E.\} and Chava Kimchi-Sarfaty",

year = "2025",

month = oct,

day = "1",

doi = "10.1093/procel/pwaf028",

language = "English",

volume = "16",

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journal = "Protein and Cell",

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Lin, BC, Jankowska, KI, Katneni, UK, Amarasinghe, R, Padhiar, N, Hamasaki-Katagiri, N, Wu, WW, Zhu, H, Taguchi, H, Ghosh, A, Holcomb, DD, Phue, J-N, Fumagalli, SE, Freedberg, DI, Kimchi, O, Shen, R-F, Komar, AA, Sauna, ZE & Kimchi-Sarfaty, C 2025, 'Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity', Protein and Cell, vol. 16, no. 10, pp. 905-910. https://doi.org/10.1093/procel/pwaf028

TY - JOUR

T1 - Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity

AU - Lin, Brian C.

AU - Jankowska, Katarzyna I.

AU - Katneni, Upendra K.

AU - Amarasinghe, Randilu

AU - Padhiar, Nigam

AU - Hamasaki-Katagiri, Nobuko

AU - Wu, Wells W.

AU - Zhu, Haojie

AU - Taguchi, Hideki

AU - Ghosh, Arnab

AU - Holcomb, David D.

AU - Phue, Je-Nie

AU - Fumagalli, Sarah E.

AU - Freedberg, Darón I.

AU - Kimchi, Ofer

AU - Shen, Rong-Fong

AU - Komar, Anton A

AU - Sauna, Zuben E.

AU - Kimchi-Sarfaty, Chava

PY - 2025/10/1

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U2 - 10.1093/procel/pwaf028

DO - 10.1093/procel/pwaf028

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SN - 1674-800X

VL - 16

SP - 905

EP - 910

JO - Protein and Cell

JF - Protein and Cell

IS - 10

ER -

Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity

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