Nolan Holland, Ph.D.
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 Title: Associate Professor
 Dept: Chemical & Biomedical Engineering
 Office: FH 462
 Phone: 216-687-2572,  216-875-9934
 Email: N.HOLLAND1@csuohio.edu
 Web: http://academic.csuohio.edu/holland_n/
 Address: 2121 Euclid Ave. FH 462, Cleveland, OH 44115

Courses Taught

Publications


Faculty Only:
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Research Keywords:
Biosynthesis of responsive polymers, Elastin like polypeptides, Atomic Force Microscopy AFM, Circular dichroism spectroscopy, Surface pressure isotherms, Surface modification, Antifreeze proteins, Biomaterials, Protein design & expression, High performance liquid chromatography HPLC, Ice crystal growth, Biologically based materials, Tissue Engineering Scaffolds, Drug delivery hydrogel particles, Protein Nuclear Magnetic Resonance (NMR) Spectroscopy, Polymer micelles, Theranostics
 
Education:
Ph.D., Macromolecular Science, Case Western Reserve University, 1999
M.S., Macromolecular Science, Case Western Reserve University, 1996
B.S., Polymer Science & Engineering, Case Western Reserve University, 1994
 
Brief Bio:
Before joining the Chemical and Biomedical Engineering Department in 2004, Professor Holland performed postdoctoral research for five years in three different laboratories.  In Biomedical Engineering at Case Western Reserve University, he investigated poly(ethylene oxide) materials as biomedical coatings and for drug delivery applications.  As a Humboldt fellow at the Ludwig-Maximilians-University in Munich, Germany, he worked in the laboratory of Hermann Gaub investigating single molecules with atomic force microscopy.  He returned to Case Western Reserve University, this time in the Physiology & Biophysics Department in the Medical School, to investigate the structure of antifreeze proteins using nuclear magnetic resonance (NMR) spectroscopy.  Prof. Holland earned his B.S., M.S., and Ph.D. degrees in the Macromolecular Science Department at Case Western Reserve University.
 
Honors and Awards:
Graduate Faculty Travel Award (2014)
Alexander von Humboldt Foundation Renewed Research Stay (2012)
Fenn College of Engineering Outstanding Research Faculty Award (2010)
Chemical & Biomedical Engineering Most Outstanding Faculty Member (2009)
NIH Postdoctoral Traineeship (2002-2004)
Alexander von Humboldt Postdoctoral Research Fellowship (2000-2001)
Graduate Student Symposium Oral Competition Finalist (1999)
Society for Biomaterials Whitaker Travel Award (1997, 1998, 2000)
American Society for Artificial Internal Organs Travel Fellowship (1995)
Graduate Traineeship (Whitaker Foundation)
NSF Graduate Fellowship Honorable Mention (1994)
Samuel Maron Memorial Award (1994; Outstanding Senior in Polymer Engineering)
Hal Loranger Award for Polymer Science (1994; Undergraduate Research)
Albert W. Smith Scholarship (1990-1994)
Caroline Knox Foundation Scholarship (1990-1994)
Elks National Scholarship (1990)
Stevenson Scholarship (1990)
 
Research Interests:
Antifreeze protein for tissue/organ preservation
Responsive polymers
Biosynthesis of protein-based polymers
Mechanics of single biomolecules
Self-assembly of polymer surfactants
 
Teaching Areas:
Biomaterials
Polymers
Materials Science
Tissue Engineering
Interfacial Phenomena
Medical Device Design
 
Professional Affiliations:
Society for Biomaterials
American Chemical Society
American Association for the Advancement of Science
Tau Beta Pi
 
Professional Experience:
Department of Chemical & Biomedical Engineering
Cleveland State University, Cleveland, OH
Assistant Professor August 2004-August 2009
Associate Professor August 2009-present

Department of Physiology & Biophysics
Case Western Reserve University, Cleveland, OH
Research Associate November 2001-August 2004

Department of Physics
John Carroll University, University Heights, OH
Part-time Instructor August 2003-December 2003

Department of Physics, Chair of Applied Physics
Ludwig-Maximilians-University, Munich, Germany
Research Assistant January 2000-September 2001

Biomedical Engineering Department
Case Western Reserve University, Cleveland, OH
Research Assistant June 1999-December 1999
 
University Service:
College Faculty Secretary, 2004-2008
Applied Biomedical Engineering Steering Committee, 2004-present
Applied Biomedical Engineering Admissions Committee, 2006-2013
Cellular and Molecular Medicine Coordinating Committee, 2005-present
Lubrizol Scholarship Selection Committee, 2005-2009
Chemical & Biomedical Engineering Department Chair Search Committee, 2005-2006
BGES Molecular Medicine Faculty Search Committee, 2005-2006
Graduate Admissions & Standards Committee, August 2007-August 2009
Industrial Research Advisory Group, August 2008-February 2009
Research Advisory Group (Convener), January-February 2009
Choose Ohio First Bioscience & Healthcare Coordinating Committee - July 2008-present
Biomedical Engineering Masters Admissions Committee, August 2009-2013
BME Faculty Search Committee, May 2010-March 2011
BME Faculty Search Committee, August 2012-May 2013
Tau Beta Pi Faculty Advisor, October 2012-present
ChE Instructor Search Committee, March 2013-August 2013
ChE Faculty Search Committee, August 2013-May 2014
 
Community Service:
Mentor for Gilmour Academy Catalyst Program
Mentor for Senior Project from Orange High School
Volunteer at Zelma George Family Shelter, Cleveland
Volunteer at Operation New Creation, New Orleans (flood recovery)
Volunteer at Greater Cleveland Habitat for Humanity
Webelos Den Leader, Cub Scout Pack 11
 
Research Grants:
Stabilization of Plasma Membranes During Cold-Temperature Storage Using Antifreeze Proteins
American Heart Association, National Scientist Development Grant, 7/2006-6/2010

Biosynthesis of Molecular Scale Responsive Materials
University Research Council, Faculty Research Development Program, 7/2007-6/2008

Optimization of Biosynthesis and Purification of Proteins and Polypeptides
Cleveland State University Undergraduate Summer Research Program, 5/2008-8/2008

Protecting Cell Membranes During Cold-Storage Using Antifreeze Proteins
Cleveland State University Undergraduate Summer Research Program, 5/2009-8/2009

Synthesis and Characterization of Functional Molecular Building Blocks for Responsive Materials
NSF, Materials World Network, 8/2009-7/2012

Design and Characterization of Thermally responsive Nanoparticles
CSU Undergraduate Summer Research (PI: K Streletzky, Physics Department),  5/2010-8/2010

Protein Purification Using an Elastin-Like Polypeptide Tag
CSU Undergraduate Summer Research, 5/2011-8/2011

Thermally Responsive Nanoparticles: Design and Characterization
CSU Undergraduate Summer Research (co-PI: K Streletzky, Physics Department), 5/2011-8/2011

MRI: Acquisition of an NMR Spectrometer
NSF Major Research Instruments Program (PI: X-L Sun (PI), co-PIs: J Masnovi & B Su), 9/2011-8/2014

Study of Polypeptide Micelles
CSU Undergraduate Summer Research (PI: K Streletzky, Physics Department), 5/2012-8/2012

Controlling the Shape and Size of Polypeptide Colloidal Particles
CSU Undergraduate Summer Research (co-PI: K Streletzky, Physics Department), 5/2013-8/2013

Characterization of Drug Loading and Stability in Theranostic Nanoparticles
University Research Council Faculty Research Development Program, 7/2013-6/2014

MRI: Acquisition of an integrated atomic force microscope/ Inverted optical microscope for interdisciplinary research at Cleveland State University
NSF Major Research Instruments Program (PI:C Kothapalli, co-PIs:A Resnick, X-L Sun & O Talu), 9/2013-8/2016

Controlling micelle formation using mixtures of linear and foldon-capped polypeptides (ELP)
CSU Undergraduate Summer Research (PI: K Streletzky, Physics Department), 5/2014-8/2014

Can elastin-like polypeptides be used as drug carrier material?: A compatibility study
CSU Undergraduate Summer Research, 5/2014-8/2014