Roman V Kondratov
 Title: AVP Research & Professor
 Dept: Biological, Geological and Environmental Sciences
 Office: SR 270-271
 Phone: 216-523-7199
 Address: 2121 Euclid Ave. SR 270-271, Cleveland, OH 44115

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Research Keywords:
aging, circadian clock, circadian system, circadian rhythms, stem cells, metabolism, caloric restriction, dietary restriction, nutrient response, osteoporosis, genotoxic stress, reactive oxygen species, circadian behavior
Ph.D., Enhelhardt Institute of Molecular Biology
Brief Bio:
Dr. Kondratov obtained his M.S. in Physics and Mathematics from Moscow Institute of Physics and Technology, his PhD in Molecular and Cellular Biology from Enhelhardt Institute of Molecular Biology (with Dr. Peter Chumakov), and has post-graduate training in University of Illinois at Chicago (with Dr. Andrei Gudkov) and Cleveland Clinic Foundation (with Dr. Marina Antoch). He joined Cleveland State University in 2006.
Research Interests:
Our laboratory were instrumental in establishing a connection between the circadian clock and aging.
"The circadian system" or the circadian clock is a internal genetically determined time keeping mechanism, which was developed by many organisms, from single cellular bacteria and fungi up to mammals including human, in order to adapt to 24-hour light/dark cycle. It was known for years that the circadian system controls many behavioral processes such as daily locomotor activity and sleep/wake cycle. What was emerging over last years is that the circadian clock is key regulator of metabolism, cardiovascular physiology, immune and stress response systems.
We have reported that knockout of the key circadian protein BMAL1 results in syndrome of early aging in mice - the significantly reduced life span (9 months for knockout vs. 28 months for wild type animals) and the development of multiple age-related pathologies (such as sarcopenia, osteoporosis, reduction of subcutaneous adipose tissue, decreased hair growth, cataracts, cornea inflammation, etc.).

Being a transcriptional factor, BMAL1 may orchestrate or influence many metabolic pathways in the organism. Therefore, different mechanisms may be responsible for aging and for the development of particular pathologies in BMAL1 deficient animals. Currently we have several projects related to the study the role of BMAL1 and circadian clock in the regulation of aging. One direction is study of aging associated signaling pathways such as TOR signaling pathways, Sirtuin signaling pathway and insulin-like growth factor/insulin-like growth factor receptor (IGF/IGFR) pathway. All these pathways play important role in cell metabolism and proliferation and organism response to nutrients and stress. These pathways are tightly regulated and disruption of the regulation is the major determinant of aging and age-related pathologies.

Another interest of the laboratory is circadian clock dependent mechanisms of dietary restriction. Dietary restriction and calorie restriction particularly is one of the most powerful interventions, which extend longevity in different organisms including mammals. We found that calorie restriction significantly affect circadian rhythms in gene expression and that functional circadian clock is necessary for lifespan extension by calorie restriction.
Stem cell homeostasis is implicated in the control of aging. We are concentrated on circadian clock mechanisms in mesenchymal stem cells and, specifically, on the role of clock proteins in osteoblast differentiation. This research will help to establish involvement of the circadian clock in such age associated pathology as osteoporosis.

We use in vitro to in vivo systems, and different techniques and approaches in order to uncover the molecular mechanisms of the circadian control of aging. We are trying to understand the nature of such a principal factor in the aging process as the organism-environment interaction, and to iden
Research Grants:

NIH 1 R01 AG039547-01A1 Role PI; 09.15.2011 ¿ 08.31.2016 Total cost: $1,455,000.00 ¿Circadian clock and dietary restriction¿.

AHA SDG 0835155N   Role: PI;   07.01.2008 ¿ 06.30.2013;    Total cost: $308,000.00; ¿Pharmacological modulation of circadian clock in cardiovascular system¿.  


NIH 1 R03 AG033881-01 Role PI; 03.01.2010 ¿ 02.28.2012; Total cost: $116,440.00;  ¿Circadian control of ROS homeostasis¿

CSU Scholarship Initiative. Role PI 07.01.2010 ¿ 06.30.2011 Total cost $5,000.00 ¿Role of BMAL1 protein in osteoblast differentiation¿  

FRD-Faculty Research and Development Award. Role: PI;  07.01.2008 ¿ 06.30.2011; Total cost $15,000.00; ¿BMALI and Oxidative Stress Response in Adult Stem Cells¿

State of Ohio Third Frontier/Ohio Board of Regents, Ohio Research Scholars Center of Research Excellence in Molecular Cardiovascular Innovation Role PI: 03.15.2009 ¿ 03.14.2010; Total cost $30,000.00; ¿Circadian Control of Antioxidant Defense, Platelet Reactivity and Thrombosis¿